SynthesisCanadian family physician Medecin de famille canadien2019
Colorectal cancer screening for patients with a family history of colorectal cancer or adenomas.
Synthesis in Canadian family physician Medecin de famille canadien, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06242197 (Comparing the Effectiveness of Written Advice VS. Standard Verbal Advice in Transferring Knowledge to First Degree Relatives of Colorectal Cancer Patients), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing the Effectiveness of Written Advice VS. Standard Verbal Advice in Transferring Knowledge to First Degree Relatives of Colorectal Cancer Patients
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population.The Cochrane database of systematic reviews · 2026Pooled it
- A comprehensive systematic review of colorectal cancer screening clinical practices guidelines and consensus statements.British journal of cancer · 2023Pooled it
- Systematic review of shared decision-making in guidelines about colorectal cancer screening.European journal of cancer care · 2022Pooled it
- Article
- Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population.The Cochrane database of systematic reviews · 2026Review
- Colonoscopy-detected high-risk adenomas and their association with alcohol consumption among first-degree relatives: an observational case-control study.Frontiers in oncology · 2026Article
- Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm.Inflammopharmacology · 2025Review
- Prevalence of Screening Colonoscopy among the First-Degree Relatives of Patients with Colorectal Cancer and Related Factors.Middle East journal of digestive diseases · 2025Article
- Review
- Gut microbiome differences and disease risk in colorectal cancer relatives and healthy individuals.Frontiers in cellular and infection microbiology · 2025Article
- Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating Occurrence.Cellular and molecular gastroenterology and hepatology · 2025Review
- Adult ileocecal intussusception as an unusual presentation of ascending colon adenocarcinoma: a case report from Sudan.Journal of surgical case reports · 2024Article
- National Trends in the Incidence of Sporadic Malignant Colorectal Polyps in Young Patients (20-49 Years): An 18-Year SEER Database Analysis.Medicina (Kaunas, Lithuania) · 2024Article
- Review
- The frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among PERSIAN Guilan Cohort Study population (PGCS).BMC gastroenterology · 2024Article
- Provincial variation in colorectal cancer screening adherence in Canada; evidence from the Canadian Partnership for Tomorrow's Health.Frontiers in oncology · 2023Article
- Colorectal cancer screening in Semarang, Indonesia: A multicenter primary health care based study.PloS one · 2023Article
- RAB27A promotes the proliferation and invasion of colorectal cancer cells.Scientific reports · 2022Article
- Uptake and Short-term Outcomes of High-risk Screening Colonoscopy Billing Codes: A Population-based Study Among Young Adults.Journal of the Canadian Association of Gastroenterology · 2022Article
- A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis.Cancers · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 11 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review and summarize the recently developed Canadian Association of Gastroenterology screening recommendations for patients with a family history of colorectal cancer (CRC) or adenoma from a family medicine perspective. QUALITY OF EVIDENCE: A systematic review and meta-analysis was performed to synthesize knowledge regarding family history and CRC. The Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE were searched with the following MeSH terms: MAIN MESSAGE: Individuals who have 1 first-degree relative (FDR) with CRC or an advanced adenoma diagnosed at any age are recommended to undergo colonoscopy every 5 to 10 years starting at age 40 to 50 years or 10 years younger than the age at diagnosis of the FDR, although fecal immunochemical testing at an interval of every 1 to 2 years can be used. Individuals with FDRs with non-advanced adenomas or a history of CRC in second-degree relatives should be screened according to average-risk guidelines. Lifestyle modification can statistically significantly decrease risk of CRC and should be considered in all patients.
conclusionThese guidelines acknowledge the many factors that can increase an individual's risk of developing CRC and allow for judgment to be employed depending on the clinical scenario. Lifestyle advice already given to patients for weight, blood pressure, and heart disease management will reduce the risk of CRC if implemented, and this combined with more targeted screening for higher-risk individuals will hopefully be successful in decreasing CRC mortality in Canada.
Indexed as
Identifiers
31722908PMC6853346W2989559026What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.