ArticleBMC oral health2019
Composition and diversity of the subgingival microbiome and its relationship with age in postmenopausal women: an epidemiologic investigation.
Article in BMC oral health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- From culture-based to 16S sequencing approaches: oral microbiota changes in aging, frailty, and oral hypofunction - a systematic review.BMC oral health · 2026Pooled it
- Pathogenicity ofFrontiers in cellular and infection microbiology · 2026Article
- Hyperuricemia is associated with periodontal ligature dysbiosis in a murine model of experimental periodontitis.Journal of oral microbiology · 2026Article
- The oral microbiome in aging: a window into health and longevity.Journal of oral microbiology · 2025Review
- The Oral Microbial Ecosystem in Age-Related Xerostomia: A Critical Review.International journal of molecular sciences · 2024Review
- Oral microbial signatures associated with age and frailty in Canadian adults.Scientific reports · 2024Article
- Defining Porphyromonas gingivalis strains associated with periodontal disease.Scientific reports · 2024Article
- Alcohol Consumption and the Diversity of the Oral Microbiome in Postmenopausal Women.The Journal of nutrition · 2024Article
- Periodontal and cardiovascular therapies modify specialized pro-resolving lipid mediator (sPRLM) (LPXA4, PD1, RvE1, RvD1, and MaR1)-mediated pathway: the first pilot clinical study.Clinical oral investigations · 2023Observational
- Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator.International journal of environmental research and public health · 2023Review
- Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors.NPJ biofilms and microbiomes · 2022Article
- Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women.Journal of the American Heart Association · 2022Article
- Dietary carbohydrate intake is associated with the subgingival plaque oral microbiome abundance and diversity in a cohort of postmenopausal women.Scientific reports · 2022Article
- Association of general health and lifestyle factors with the salivary microbiota - Lessons learned from the ADDITION-PRO cohort.Frontiers in cellular and infection microbiology · 2022Article
- Microbiota in Periodontitis: Advances in the Omic Era.Advances in experimental medicine and biology · 2022Review
- Old age and other factors associated with salivary microbiome variation.BMC oral health · 2021Article
- Subgingival microbiome is associated with alveolar bone loss measured 5 years later in postmenopausal women.Journal of periodontology · 2021Article
- Subgingival Microbiome and Specialized Pro-Resolving Lipid Mediator Pathway Profiles Are Correlated in Periodontal Inflammation.Frontiers in immunology · 2021Article
- The Oral Microbiome in Periodontal Health.Frontiers in cellular and infection microbiology · 2021Article
- Impact of Local Drug Delivery of Minocycline on the Subgingival Microbiota during Supportive Periodontal Therapy: A Randomized Controlled Pilot Study.Dentistry journal · 2020Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe extent to which the composition and diversity of the oral microbiome varies with age is not clearly understood.
methodsThe 16S rRNA gene of subgingival plaque in 1219 women, aged 53-81 years, was sequenced and its taxonomy annotated against the Human Oral Microbiome Database (v.14.5). Composition of the subgingival microbiome was described in terms of centered log(2)-ratio (CLR) transformed OTU values, relative abundance, and prevalence. Correlations between microbiota abundance and age were evelauted using Pearson Product Moment correlations. P-values were corrected for multiple testing using the Bonferroni method.
resultsOf the 267 species identified overall, Veillonella dispar was the most abundant bacteria when described by CLR OTU (mean 8.3) or relative abundance (mean 8.9%); whereas Streptococcus oralis, Veillonella dispar and Veillonella parvula were most prevalent (100%, all) when described as being present at any amount. Linear correlations between age and several CLR OTUs (Pearson r = - 0.18 to 0.18), of which 82 (31%) achieved statistical significance (P < 0.05). The correlations lost significance following Bonferroni correction. Twelve species that differed across age groups (each corrected P < 0.05); 5 (42%) were higher in women ages 50-59 compared to ≥70 (corrected P < 0.05), and 7 (48%) were higher in women 70 years and older.
conclusionsWe identified associations between several bacterial species and age across the age range of postmenopausal women studied. Understanding the functions of these bacteria could identify intervention targets to enhance oral health in later life.
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