Observational studyTherapeutic advances in respiratory disease
Noninvasive ventilation failure in patients with hypoxemic respiratory failure: the role of sepsis and septic shock.
Observational study in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Development and evaluation of an ontology for non-invasive respiratory support in acute care.PloS one · 2026Article
- Prediction of noninvasive ventilation failure: a narrative review.Annals of intensive care · 2026Review
- Comparison of the clinimetric properties of the two versions of the HACOR scale for predicting noninvasive ventilation failure in Brazilian patients.Acute and critical care · 2025Article
- Comparison of high-flow nasal oxygen therapy and noninvasive ventilation in suspected sepsis patients with acute respiratory distress in the emergency department: a retrospective cohort study.International journal of emergency medicine · 2025Article
- Intercostal Muscle Function During Noninvasive Ventilation and Acute Hypercapnic Respiratory Failure.Respiratory care · 2024Article
- Article
- Non-Invasive Ventilation for Community-Acquired Pneumonia: Outcomes and Predictors of Failure from an ICU Cohort.Medicina (Kaunas, Lithuania) · 2023Observational
- An updated HACOR score for predicting the failure of noninvasive ventilation: a multicenter prospective observational study.Critical care (London, England) · 2022Observational
- Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study.The American journal of emergency medicine · 2021Observational
- Voluntary Prone Position for Acute Hypoxemic Respiratory Failure in Unintubated Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
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Authors and funding
28 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis and septic shock are common in noninvasive ventilation (NIV) patients. However, studies on the association between sepsis and NIV failure are lacking.
methodsA prospective multi-center observational study was performed in 16 Chinese intensive care units (ICUs). Patients who used NIV due to hypoxemic respiratory failure were enrolled. Sepsis and septic shock were diagnosed according to the guideline of sepsis-3.
resultsA total of 519 patients were enrolled. Sepsis developed in 365 patients (70%) and septic shock developed in 79 patients (15%). However, 75 patients (14%) had no sepsis. NIV failure was 23%, 38%, and 61% in patients, with no sepsis, sepsis, and septic shock, respectively. Multivariate analysis found that sepsis [odds ratio (OR) = 1.95, 95% confidence interval (CI): 1.06-3.61] and septic shock (OR = 2.47, 95% CI: 1.12-5.45) were independently associated with NIV failure. In sepsis and septic shock population, the NIV failure was 13%, 31%, 37%, 53%, and 67% in patients with sequential organ failure assessment (SOFA) scores of ⩽2, 3-4, 5-6, 7-8, and ⩾9, respectively. Patients with nonpulmonary induced sepsis had similar NIV failure rate compared with those with pulmonary induced sepsis, but had higher proportion of septic shock (37%
conclusionsSepsis was associated with NIV failure in patients with hypoxemic respiratory failure, and the association was stronger in septic shock patients. NIV failure increased with the increase of organ dysfunction caused by sepsis.
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