ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020
Characterizing pulsatility in distal cerebral arteries using 4D flow MRI.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion.The Journal of physiology · 2021Trial
- Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition.GeroScience · 2026Article
- Noninvasive Pulse Measurements for Cardiovascular Health Monitoring and Diagnoses.Advances in experimental medicine and biology · 2026Review
- Imaging blood to periarterial CSF flow coupling using 4D flow MRI and an ultra-high-performance head-only gradient system.Fluids and barriers of the CNS · 2025Article
- Arterial-optimized 4D-flow MRI for quantifying flow and pulsatility in venous sinuses and large cerebral veins.Scientific reports · 2025Article
- Simultaneous Assessment of Arterial Pulsatility Across Multiple Segments of Cerebral Arteries Using Multiband Dual-VENC Phase-Contrast MRI.NMR in biomedicine · 2025Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- Blood Flow Velocity Analysis in Cerebral Perforating Arteries on 7T 2D Phase Contrast MRI with an Open-Source Software Tool (SELMA).Neuroinformatics · 2025Article
- Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults.Fluids and barriers of the CNS · 2025Article
- Sex differences in gray matter, white matter, and regional brain perfusion in young, healthy adults.American journal of physiology. Heart and circulatory physiology · 2024Article
- CSF dynamics throughout the ventricular system using 4D flow MRI: associations to arterial pulsatility, ventricular volumes, and age.Fluids and barriers of the CNS · 2024Article
- Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Blood-brain barrier integrity is linked to cognitive function, but not to cerebral arterial pulsatility, among elderly.Scientific reports · 2024Article
- Four-dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities.NMR in biomedicine · 2024Review
- Measuring global cerebrovascular pulsatility transmission using 4D flow MRI.Scientific reports · 2024Article
- The impact of body position on neurofluid dynamics: present insights and advancements in imaging.Frontiers in aging neuroscience · 2024Review
- Cerebral arterial flow dynamics during systole and diastole phases in young and older healthy adults.Fluids and barriers of the CNS · 2023Article
- Cell non-autonomous regulation of cerebrovascular aging processes by the somatotropic axis.Frontiers in endocrinology · 2023Review
- Longitudinal stability in working memory and frontal activity in relation to general brain maintenance.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports have suggested that age-related arterial stiffening and excessive cerebral arterial pulsatility cause blood-brain barrier breakdown, brain atrophy and cognitive decline. This has spurred interest in developing non-invasive methods to measure pulsatility in distal vessels, closer to the cerebral microcirculation. Here, we report a method based on four-dimensional (4D) flow MRI to estimate a global composite flow waveform of distal cerebral arteries. The method is based on finding and sampling arterial waveforms from thousands of cross sections in numerous small vessels of the brain, originating from cerebral cortical arteries. We demonstrate agreement with internal and external reference methods and show the ability to capture significant increases in distal cerebral arterial pulsatility as a function of age. The proposed approach can be used to advance our understanding regarding excessive arterial pulsatility as a potential trigger of cognitive decline and dementia.
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