Evidence map›Paper›PMID 31722540›Full record

ArticleCirculation. Cardiovascular quality and outcomes2019

Comparative Performance of Prediction Models for Contrast-Associated Acute Kidney Injury After Percutaneous Coronary Intervention.

Bryan Ma, David W Allen, Michelle M Graham, Bryan J Har, Ben Tyrrell, Zhi Tan, John A Spertus, Jeremiah R Brown, Michael E Matheny, Brenda R Hemmelgarn and 2 more

Open access · bronzeAbstract readComparative StudyValidation Study
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  11. Mehran 2 Contrast-Associated Acute Kidney Injury Risk Score: Is it Applicable to the Asian Percutaneous Coronary Intervention Population?Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Bryan MaDepartment of Medicine (B.M., Z.T., B.R.H., M.T.J.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
David W AllenDepartment of Cardiac Sciences, University of Manitoba, Winnipeg, Canada (D.W.A.).
Michelle M GrahamDepartment of Medicine, Faculty of Medicine, Mazinkowski Alberta Heart Institute, University of Alberta, Canada (M.M.G., B.T., N.P.).
Bryan J HarDepartment of Cardiac Sciences, Libin Cardiovascular Institute of Alberta (B.J.H.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
Ben TyrrellDepartment of Medicine, Faculty of Medicine, Mazinkowski Alberta Heart Institute, University of Alberta, Canada (M.M.G., B.T., N.P.).
Zhi TanDepartment of Medicine (B.M., Z.T., B.R.H., M.T.J.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
John A SpertusDepartments of Biomedical and Health Informatics, University of Missouri-Kansas City, Saint Luke's Mid America Heart Institute (J.A.S.).
Jeremiah R BrownThe Dartmouth Institute for Health Policy and Clinical Practice, Departments of Epidemiology and Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH (J.R.B.).
Michael E MathenyDepartment of Biomedical Informatics, Vanderbilt University, Nashville, TN (M.E.M.).
Brenda R HemmelgarnDepartment of Medicine (B.M., Z.T., B.R.H., M.T.J.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
Neesh PannuDepartment of Medicine, Faculty of Medicine, Mazinkowski Alberta Heart Institute, University of Alberta, Canada (M.M.G., B.T., N.P.).
Matthew T JamesDepartment of Medicine (B.M., Z.T., B.R.H., M.T.J.), Cumming School of Medicine, University of Calgary, Alberta, Canada.
Libin Cardiovascular Institute of Alberta · CAUniversity of Calgary · CADartmouth Institute for Health Policy and Clinical Practice · USSaint Luke's Health System · USUniversity of Manitoba · CAVanderbilt University · US

Funding

IMPROVE-AKI: A Cluster-Randomized Trial of Team-Based Coaching Interventions to IMPROVE Acute Kidney InjuryR01DK113201 · NIDDK · DARTMOUTH COLLEGE · PI Jeremiah R Brown, MICHAEL E. MATHENY · 2018 to 2026
$5.1M
CIHR MOP137040NIDDK NIH HHS R01 DK113201
6 · The paper itself

Abstract

backgroundIdentifying patients at increased risk of contrast-associated acute kidney injury (CA-AKI) can help target risk mitigation strategies toward these individuals during percutaneous coronary intervention. Illuminating which risk models best stratify risk is an important foundation for such quality improvement efforts. METHODS AND

resultsSeven previously published risk prediction models for CA-AKI and 3 models for kidney injury requiring dialysis were validated using 2 definitions for CA-AKI (the Kidney Disease: Improving Global Outcomes definition of ≥0.3 mg/dL within 48 hours or ≥50% increase in serum creatinine from baseline within 7 days and the historical definition of ≥0.5 mg/dL or ≥25% increase in serum creatinine from baseline within 48 hours), and AKI requiring dialysis within 30 days of percutaneous coronary intervention. Model performance was compared based on discrimination, calibration, and categorical net reclassification index before and after model recalibration. Among 7888 patients who underwent percutaneous coronary intervention in Alberta Canada, CA-AKI occurred in 330 patients (4.2%) when CA-AKI was defined using the Kidney Disease: Improving Global Outcomes definition and 571 (7.3%) when using the historical definition. CA-AKI requiring dialysis occurred in 42 (0.6%) patients. When validated using the Kidney Disease: Improving Global Outcomes definition for CA-AKI, the 2 most recently published models for CA-AKI showed better discrimination (C statistics, 0.75-0.76) than older models (C statistics, 0.61-0.68). C statistics of models for kidney injury requiring dialysis ranged from 0.70 to 0.86. The calibration of all models for CA-AKI deviated from ideal, and the proportion of patients classified into different risk categories for CA-AKI differed substantially for the 2 most recent models. Recalibration significantly improved risk stratification of patients into clinical risk categories for some models.

conclusionsRecent prediction models for CA-AKI show better discrimination compared with older models; however, model recalibration should be examined in external cohorts to improve the accuracy of predictions, particularly if predicted risk strata are used to guide management approaches.

Indexed as

Decision Support TechniquesModels, BiologicalAcute Kidney InjuryAgedAged, 80 and overContrast MediaFemaleHumansMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsRadiography, InterventionalRenal DialysisReproducibility of ResultsRisk AssessmentContrast Mediaacute kidney injurycalibrationkidneypercutaneous coronary interventionquality improvement

Identifiers

PMID31722540
PMCPMC12375386
OpenAlexW2987096433

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.