Evidence map›Paper›PMID 31722437›Full record

ArticleBritish journal of pharmacology2020

The novel antipsychotic cariprazine stabilizes gamma oscillations in rat hippocampal slices.

Maria A Meier, Clement E Lemercier, Christoph Kulisch, Béla Kiss, Balázs Lendvai, Nika Adham, Zoltan Gerevich

Abstract read
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. The structure of the dopamine DScience advances · 2026
    Article
  2. Article
  3. Article
  4. Abnormal spontaneous activity and rest-task shift in schizophrenia.Psychiatry and clinical neurosciences · 2025
    Article
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  6. Article
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria A MeierInstitute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Clement E LemercierInstitute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Christoph KulischInstitute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Béla KissPharmacological and Drug Safety Research, Gedeon Richter Plc, Budapest, Hungary.
Balázs LendvaiPharmacological and Drug Safety Research, Gedeon Richter Plc, Budapest, Hungary.
Nika AdhamExternal Science and Innovation, Allergan Plc, Madison, New Jersey, USA.
Zoltan GerevichInstitute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-4684-6100

Funding

Allergan PlcGedeon Richter Plc
6 · The paper itself

Abstract

background and purposeGamma oscillations are fast rhythmic fluctuations of neuronal network activity ranging from 30 to 90 Hz that establish a precise temporal background for cognitive processes such as perception, sensory processing, learning, and memory. Alterations of gamma oscillations have been observed in schizophrenia and are suggested to play crucial roles in the generation of positive, negative, and cognitive symptoms of the disease. EXPERIMENTAL APPROACH: In this study, we investigated the effects of the novel antipsychotic cariprazine, a D KEY

resultsThe D CONCLUSION AND IMPLICATIONS: Data from this study indicate that cariprazine stabilizes pathological hippocampal gamma oscillations, presumably by its partial agonistic profile. The results demonstrate in vitro gamma oscillations as predictive biomarkers to study the effects of antipsychotics preclinically at the network level.

Indexed as

Antipsychotic AgentsAnimalsHippocampusPiperazinesRatsReceptors, Dopamine D3Antipsychotic AgentscariprazinePiperazinesReceptors, Dopamine D3

Identifiers

PMID31722437
PMCPMC7060372

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.