ArticleThe Journal of infectious diseases2020
Human Immunodeficiency Virus Infection Is Associated With Preterm Delivery Independent of Vaginal Microbiota in Pregnant African Women.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis.Scientific reports · 2022Pooled it
- Human microbiota research in Africa: a systematic review reveals gaps and priorities for future research.Microbiome · 2021Pooled it
- Trial
- Combined effects of bacterial vaginal colonization and HIV on pregnancy outcomes: A Systematic Review and Meta-analysis.Research square · 2026Article
- Article
- Vaginal Microbiome and the Risk of Preterm Birth in Women Living With HIV: A Scoping Review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Changes in the Vaginal Microbiome During Pregnancy and the Postpartum Period in South African Women: a Longitudinal Study.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Changes in the vaginal microbiome during pregnancy and the postpartum period in South African women: a longitudinal study.Research square · 2023Article
- Microbiota dynamics, metabolic and immune interactions in the cervicovaginal environment and their role in spontaneous preterm birth.Frontiers in immunology · 2023Review
- Roles of the Microbiota of the Female Reproductive Tract in Gynecological and Reproductive Health.Microbiology and molecular biology reviews : MMBR · 2022Review
- Clinical and programmatic outcomes of HIV-exposed infants enrolled in care at geographically diverse clinics, 1997-2021: A cohort study.PLoS medicine · 2022Article
- Prediction and prevention of preterm birth in pregnant women living with HIV on antiretroviral therapy.Expert review of anti-infective therapy · 2022Review
- HIV-associated vaginal microbiome and inflammation predict spontaneous preterm birth in Zambia.Scientific reports · 2022Article
- Associations between HIV, antiretroviral therapy and preterm birth in the US Women's Interagency HIV Study, 1995-2018: a prospective cohort.HIV medicine · 2022Article
- The Vaginal Microbiota Composition and Genital Infections during and after Pregnancy among Women in Pemba Island, Tanzania.Microorganisms · 2022Article
- Lactobacillus crispatus thrives in pregnancy hormonal milieu in a Nigerian patient cohort.Scientific reports · 2021Article
- Composition of the vaginal microbiota during pregnancy in women living in sub-Saharan Africa: a PRISMA-compliant review.BMC pregnancy and childbirth · 2021Review
- Aetiological testing compared with syndromic management for sexually transmitted infections in HIV-infected pregnant women in South Africa: a non-randomised prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2021Article
- Predominance of Atopobium vaginae at Midtrimester: a Potential Indicator of Preterm Birth Risk in a Nigerian Cohort.mSphere · 2021Article
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundDuring pregnancy, the vaginal microbiota is relatively stable. However, African women have more diverse vaginal microbiota than their European counterparts, in addition to high human immunodeficiency virus (HIV) prevalence and risk of adverse birth outcomes. Although HIV is associated with alterations in vaginal microbiota and inflammation in nonpregnant women, these relationships are underexplored in pregnant women.
methodsIn this study, we characterize the vaginal microbiota and immune factors in pregnant African women who were HIV-uninfected (n = 314) versus HIV-infected (n = 42). Mucosal samples were collected once at the enrollment visit (between 15 and 35 weeks of gestation) and women were followed until delivery.
resultsVaginal microbial communities of pregnant women with HIV were significantly more diverse than women without HIV (P = .004), with community structure also differing by HIV status (P = .002, R2 = 0.02). Human immunodeficiency virus infection was also associated with increased risk of preterm birth (PTB) (31% versus 15.3%; P = .066). In a multivariate analysis, HIV infection was independently associated with diverse vaginal community state type (CST)-IVA (P = .005) and CST-IVB (P = .018) as well as PTB (P = .049). No association between HIV status and cytokine concentrations was found.
conclusionsLongitudinal studies with accurate gestational age assessment would be important to confirm these relationships.
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