ArticleEuropean heart journal. Cardiovascular Imaging2020
The impact of visceral and general obesity on vascular and left ventricular function and geometry: a cross-sectional magnetic resonance imaging study of the UK Biobank.
Article in European heart journal. Cardiovascular Imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 39 citations in OpenAlex.
- Near-universal prevalence of central adiposity in heart failure with preserved ejection fraction: the PARAGON-HF trial.European heart journal · 2025Trial
- Cardiovascular disease and metabolic dysfunction-associated steatotic liver disease incidence in metabolically healthy and unhealthy normal weight obesity.International journal of obesity (2005) · 2026Article
- Centralized Review of Alzheimer's Disease and Related Dementias Biomedical Repositories and Computational Methods.Bioengineering (Basel, Switzerland) · 2026Review
- A study on the correlation between cardiac magnetic resonance characteristics and myocardial fibrosis in overweight and obese individuals.BMC medical imaging · 2026Article
- Sex differences in the relationship between body composition and cardiac structure and function.European heart journal. Cardiovascular Imaging · 2025Article
- Effect of fat distribution on left ventricular structure and function in different sexes: a Mendelian randomization study.Frontiers in endocrinology · 2025Article
- [Left Ventricular Structural and Functional Changes in Obese Subjects With Preserved Left Ventricular Ejection Fraction After Bariatric Surgery: Assessment With Cardiac Magnetic Resonance Imaging].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Article
- The effect of hyperlipidemia and body fat distribution on subclinical left ventricular function in obesity: a cardiovascular magnetic resonance study.Cardiovascular diabetology · 2024Article
- Myocardial tissue remodeling in early adult obesity and its association with regional adipose tissue distribution and ectopic fat deposits: a prospective study.European radiology · 2024Article
- The role of obesity-related cardiovascular remodelling in mediating incident cardiovascular outcomes: a population-based observational study.European heart journal. Cardiovascular Imaging · 2023Observational
- Defining left ventricular remodeling using lean body mass allometry: a UK Biobank study.European journal of applied physiology · 2023Article
- Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: a CMR study of 42 598 UK Biobank participants.European heart journal. Cardiovascular Imaging · 2022Article
- Estimation of biological heart age using cardiovascular magnetic resonance radiomics.Scientific reports · 2022Article
- Effects of canagliflozin and metformin on insulin resistance and visceral adipose tissue in people with newly-diagnosed type 2 diabetes.BMC endocrine disorders · 2022Article
- Ectopic fat is associated with cardiac remodeling-A comprehensive assessment of regional fat depots in type 2 diabetes using multi-parametric MRI.Frontiers in cardiovascular medicine · 2022Article
- Electrocardiographic QRS duration is influenced by body mass index and sex.International journal of cardiology. Heart & vasculature · 2021Article
- The patterns of left ventricular alteration by adipose tissue distribution: implication for heart failure prevention.ESC heart failure · 2021Article
- Cardiovascular magnetic resonance imaging in the UK Biobank: a major international health research resource.European heart journal. Cardiovascular Imaging · 2021Article
- Obesity and the heart: The impact of obesity beyond the body mass index.European journal of preventive cardiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe aimed to evaluate the associations of body fat distribution with cardiovascular function and geometry in the middle-aged general population. METHODS AND
resultsFour thousand five hundred and ninety participants of the UK Biobank (54% female, mean age 61.1 ± 7.2 years) underwent cardiac magnetic resonance for assessment of left ventricular (LV) parameters [end-diastolic volume (EDV), ejection fraction (EF), cardiac output (CO), and index (CI)] and magnetic resonance imaging for body composition analysis [subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT)]. Body fat percentage (BF%) was assessed by bioelectrical impedance. Linear regressions were performed to assess the impact of visceral (VAT) and general (SAT and BF%) obesity on cardiac function and geometry. Visceral obesity was associated with a smaller EDV [VAT: β -1.74 (-1.15 to -2.33)], lower EF [VAT: β -0.24 (-0.12 to -0.35), SAT: β 0.02 (-0.04 to 0.08), and BF%: β 0.02 (-0.02 to 0.06)] and the strongest negative association with CI [VAT: β -0.05 (-0.06 to -0.04), SAT: β -0.02 (-0.03 to -0.01), and BF% β -0.01 (-0.013 to -0.007)]. In contrast, general obesity was associated with a larger EDV [SAT: β 1.01 (0.72-1.30), BF%: β 0.37 (0.23-0.51)] and a higher CO [SAT: β 0.06 (0.05-0.07), BF%: β 0.02 (0.01-0.03)]. In the gender-specific analysis, only men had a significant association between VAT and EF [β -0.35 (-0.19 to -0.51)].
conclusionVisceral obesity was associated with a smaller LV EDV and subclinical lower LV systolic function in men, suggesting that visceral obesity might play a more important role compared to general obesity in LV remodelling.
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