Evidence map›Paper›PMID 31722367›Full record

ArticlePediatric research2020

Early prediction of unilateral cerebral palsy in infants at risk: MRI versus the hand assessment for infants.

Nienke Wagenaar, Cornelia H Verhage, Linda S de Vries, Bram P L van Gasselt, Corine Koopman, Alexander Leemans, Floris Groenendaal, Manon J N L Benders, Niek E van der Aa

2 registry-linked trialsAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04925102 unknown statusnot on this mapstarted 2021, after this paper: background citation

Prediction of Recovery in Spastic Cerebral Palsy.

Typeobservational_patient_registrySponsorRiphah International UniversityRan2021 to 2022Enrolled125ConditionsSpastic Cerebral PalsyArmsStandardized treatment protocol for cerebral palsy
NCT06396520 recruitingnot on this mapstarted 2024, after this paper: background citation

Neuroimaging of Babies During Natural Sleep to Assess Typical Development and Cerebral Palsy

TypeobservationalSponsorDanish Research Centre for Magnetic ResonanceRan2024 to 2027Enrolled200ConditionsCerebral Palsy, Infant Development, Development, InfantArmsNo intervention, observational
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nienke WagenaarDepartment of Neonatology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Cornelia H VerhageChild Development and Exercise Centre, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Linda S de VriesDepartment of Neonatology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Bram P L van GasseltDepartment of Neonatology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Corine KoopmanDepartment of Neonatology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Alexander LeemansImage Sciences Institute, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Floris GroenendaalDepartment of Neonatology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Manon J N L BendersDepartment of Neonatology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Niek E van der AaDepartment of Neonatology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. n.vanderaa@umcutrecht.nl.
University Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonates with unilateral perinatal brain injury (UPBI) are at risk for developing unilateral spastic cerebral palsy (USCP). This study compares several predictors for USCP later in life.

methodsTwenty-one preterm and 24 term born infants with UPBI were included, with an MRI scan including diffusion tensor imaging (DTI) performed at term equivalent age or around 3 months after birth, respectively. T2-weighted images and DTI-based tractography were used to measure the surface area, diameter, and fractional anisotropy (FA) of both corticospinal tracts (CSTs). The hand assessment for infants (HAI) was performed before 5, between 5 and 8 and between 8 and 12 months of (corrected) age. Asymmetry indices were derived from all techniques and related to USCP at ≥2 years of age.

resultsMRI measures and HAI scores were significantly lower for the affected compared to the unaffected side. Before 5 months of age, FA asymmetry on DTI yielded the highest area under the curve compared to conventional MRI and HAI.

conclusionsPrediction of USCP after UPBI is reliable using asymmetry of the CST on MRI, as well as clinical hand assessment. Before 5 months of age, DTI tractography provides strongest predictive information, while HAI specifically aids to prognosis of USCP at later age points.

Indexed as

Diffusion Tensor ImagingMagnetic Resonance ImagingBrainCerebral PalsyChild, PreschoolDisability EvaluationFemaleHandHumansInfantInfant, NewbornMaleNeonatologyRiskROC Curve

Identifiers

PMID31722367
OpenAlexW2985393265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.