Evidence map›Paper›PMID 31722231›Full record

ArticleNeuroImage2020

The potential for gas-free measurements of absolute oxygen metabolism during both baseline and activation states in the human brain.

Eulanca Y Liu, Jia Guo, Aaron B Simon, Frank Haist, David J Dubowitz, Richard B Buxton

Open access · hybridAbstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Oxygen extraction fraction (OEF) values and applications in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  2. Review
  3. Review
  4. TMagnetic resonance in medicine · 2022
    Article
  5. Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  6. High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  7. Hemodynamic and metabolic changes during hypercapnia with normoxia and hyperoxia using pCASL and TRUST MRI in healthy adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  8. Article
  9. The thermodynamics of thinking: connections between neural activity, energy metabolism and blood flow.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Eulanca Y LiuNeurosciences Graduate Program, Medical Scientist Training Program, University of California, San Diego, USA; Center for Functional MRI, University of California, San Diego, USA.
Jia GuoCenter for Functional MRI, University of California, San Diego, USA; Department of Bioengineering, University of California, Riverside, USA.
Aaron B SimonCenter for Functional MRI, University of California, San Diego, USA; Department of Radiation Medicine and Applied Sciences, University of California, San Diego, USA.
Frank HaistPsychiatry, University of California, San Diego, USA; Center for Human Development, University of California, San Diego, USA.
David J DubowitzCenter for Functional MRI, University of California, San Diego, USA; Radiology, University of California, San Diego, USA; University of Auckland, Auckland, New Zealand.
Richard B BuxtonCenter for Functional MRI, University of California, San Diego, USA; Radiology, University of California, San Diego, USA. Electronic address: rbuxton@ucsd.edu.
University of California, San Diego · USUniversity of California, Riverside · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3M
MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGINGR01MH111359 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M, DEVOR, ANNA · 2016 to 2020
$5.6M
The Physiological Basis of Functional MRIR01NS036722 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BUXTON, RICHARD BRUCE · 1998 to 2017
$5.2M
Defining Neurovascular Coupling Variability Using Quantitative Functional MRIR21MH112969 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BUXTON, RICHARD BRUCE, HAIST, FRANK · 2018 to 2019
$426k
Establishing a foundation for clinical applications of physiological quantitative fMRIF30MH113295 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIU, EULANCA YUKA · 2017 to 2018
$73k
NIGMS NIH HHS T32 GM007198NIMH NIH HHS F30 MH113295NIMH NIH HHS R01 MH111359NIMH NIH HHS R21 MH112969NINDS NIH HHS R01 NS036722
6 · The paper itself

Abstract

Quantitative functional magnetic resonance imaging methods make it possible to measure cerebral oxygen metabolism (CMRO

Indexed as

AdultBrainBrain MappingCerebrovascular CirculationFemaleHumansHypercapniaHyperoxiaImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleOxygenOxygen ConsumptionYoung AdultOxygenBlood oxygenation level dependentCerebral blood flowCerebral metabolism of oxygenFunctional MRIHypercapniaOxygen extraction fraction

Identifiers

PMID31722231
PMCPMC6995433
OpenAlexW2983184954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.