Evidence map›Paper›PMID 31722080›Full record

ArticleJournal of molecular histology2020

Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors.

Araz Ahmed, Alessandro Gulino, Simita Amayo, Walter Arancio, Ada Maria Florena, Beatrice Belmonte, Abdo Jurjus, Angelo Leone, Isabelle Miletich

Open access · hybridAbstract read
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In one paragraph

Article in Journal of molecular histology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Insight into the Role of Psychological Factors in Oral Mucosa Diseases.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Araz AhmedCentre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, Guy's Hospital, Floor 27 Guy's Tower, London, SE1 9RT, UK.
Alessandro GulinoDipartimento Di Promozione Della Salute, Materno-Infantile, Medicina Interna E Specialistica Di Eccellenza "G. D'Alessandro", University of Palermo, Palermo, Italy.
Simita AmayoCentre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, Guy's Hospital, Floor 27 Guy's Tower, London, SE1 9RT, UK.
Walter ArancioDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128, Palermo, Italy.
Ada Maria FlorenaDipartimento Di Promozione Della Salute, Materno-Infantile, Medicina Interna E Specialistica Di Eccellenza "G. D'Alessandro", University of Palermo, Palermo, Italy.
Beatrice BelmonteDipartimento Di Promozione Della Salute, Materno-Infantile, Medicina Interna E Specialistica Di Eccellenza "G. D'Alessandro", University of Palermo, Palermo, Italy.
Abdo JurjusDepartment of Anatomy, Cell Biology and Physiology, American University of Beirut, Beirut, Lebanon.
Angelo LeoneCentre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, Guy's Hospital, Floor 27 Guy's Tower, London, SE1 9RT, UK. angelo.leone@unipa.it.
Isabelle MiletichCentre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, Guy's Hospital, Floor 27 Guy's Tower, London, SE1 9RT, UK. isabelle.miletich@kcl.ac.uk.ORCID http://orcid.org/0000-0003-2817-7492
Guy's Hospital · GBUniversity of Palermo · ITAmerican University of Beirut · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.

Indexed as

AnimalsAtrial Natriuretic FactorCarcinoma, Squamous CellFemaleHumansMaleMiceMouth NeoplasmsNatriuretic Peptide, BrainNatriuretic Peptide, C-TypeNeoplasm ProteinsReceptors, PeptideSubmandibular GlandAtrial Natriuretic FactorNatriuretic Peptide, BrainNatriuretic Peptide, C-TypeNeoplasm ProteinsReceptors, PeptideAtrial natriuretic peptide, ANPAutonomic nervous systemB-type natriuretic peptide, BNPC-type natriuretic peptide, CNPNatriuretic peptide receptor A, NPRANatriuretic peptide receptor B, NPRBNatriuretic peptide receptor C, NPRCOral squamous cell carcinomaSalivary glandSubmandibular gland

Identifiers

PMID31722080
OpenAlexW2986496417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.