Evidence map›Paper›PMID 31722035›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2020

Could the severity of symptoms of schizophrenia affect ability of self-appraisal of cognitive deficits in patients with schizophrenia? Lack of insight as a mediator between the two domains.

Valeria Santarelli, Carmela Marucci, Alberto Collazzoni, Maria Cristina Rossetti, Giulia Pizziconi, Francesca Pacitti, Paolo Stratta, Alessandro Rossi, Rodolfo Rossi

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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Valeria SantarelliDepartment of Clinical and Applied Sciences and Biotechnology (DISCAB), Section of Psychiatry and Clinical Psychology, University of L'Aquila, L'Aquila, Italy. santarelli.valeria@hotmail.it.ORCID http://orcid.org/0000-0002-3053-3241
Carmela MarucciDepartment of Clinical and Applied Sciences and Biotechnology (DISCAB), Section of Psychiatry and Clinical Psychology, University of L'Aquila, L'Aquila, Italy.
Alberto CollazzoniDepartment of Clinical and Applied Sciences and Biotechnology (DISCAB), Section of Psychiatry and Clinical Psychology, University of L'Aquila, L'Aquila, Italy.
Maria Cristina RossettiDepartment of Clinical and Applied Sciences and Biotechnology (DISCAB), Section of Psychiatry and Clinical Psychology, University of L'Aquila, L'Aquila, Italy.
Giulia PizziconiDepartment of Clinical and Applied Sciences and Biotechnology (DISCAB), Section of Psychiatry and Clinical Psychology, University of L'Aquila, L'Aquila, Italy.
Francesca PacittiDepartment of Clinical and Applied Sciences and Biotechnology (DISCAB), Section of Psychiatry and Clinical Psychology, University of L'Aquila, L'Aquila, Italy.
Paolo StrattaDepartment of Mental Health, L'Aquila, Italy.
Alessandro RossiDepartment of Clinical and Applied Sciences and Biotechnology (DISCAB), Section of Psychiatry and Clinical Psychology, University of L'Aquila, L'Aquila, Italy.
Rodolfo RossiDepartment of Systems Medicine, University of Tor Vergata Rome, Rome, Italy.
University of L'Aquila · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between subjective appraisal of cognitive deficits and symptom severity in schizophrenia is unclear. Insight reportedly affects both factors. Our aim is to further asses the relationship between subjective perception of cognitive deficits, symptom severity and lack of insight as a mediator variable. 109 subjects with schizophrenia were evaluated. Positive and Negative Syndrome Scale (PANSS) was modelled as independent variable, Subjective Scale to Investigate Cognition in Schizophrenia (SSTICS) as dependent and "Lack of Insight" (LoI) PANSS Item as mediator one. Mediation was assessed using bootstrap estimation approach. LoI acts as a suppressor variable (i.e., it enhances the relation between the independent and dependent variable) between Negative Symptoms and SSTICS, while showing a mediation effect between Depressive symptoms and SSTICS. LoI has a central role in mediating the relationship between negative and depressed symptoms on the one hand and self-appraisals of cognitive deficits (SACD) assessed with SSTICS on the other. Its suppressor role between negative symptoms and STICSS favour a direct effect of negative symptoms on SACD. On the other hand, its mediator role between depression and SSTICS is consistent with several reports of the 'insight paradox' of an enhanced severity of depression in patients with higher awareness of their disability.

Indexed as

Diagnostic Self EvaluationAdultAwarenessCognitive DysfunctionCross-Sectional StudiesFemaleHumansMaleMediation AnalysisMiddle AgedSchizophreniaSeverity of Illness IndexAssessmentDepressionNegative symptomsResearch measuresSchizophrenia

Identifiers

PMID31722035
OpenAlexW2989068575

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.