Observational studyEinstein (Sao Paulo, Brazil)2020
Use of misoprostol in the treatment of postpartum hemorrhage: a pharmacoepidemiological approach.
Observational study in Einstein (Sao Paulo, Brazil), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Hyperpyrexia with hemodynamic instability after sublingual misoprostol: case report and literature review.AJOG global reports · 2026Article
- Multidisciplinary team training in postpartum hemorrhage: impact on the use of blood products.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Article
- Misoprostol Administration Before Hysteroscopy Procedures - A Retrospective Analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Observational
- Prophylactic effect of rectal and sublingual misoprostol on postpartum hemorrhage in mothers with preeclampsia following cesarean section surgery; a double-blind randomized controlled trial.Annals of medicine and surgery (2012) · 2022Article
- Effect of Baogong Zhixue Granules Combined with Tranexamic Acid Injection on the Hemodynamics and Reproductive System in Patients with Postpartum Hemorrhage after Cesarean Section.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Review
- Retrospective Study on the Pattern of Off-label Use of Misoprostol in Tabuk, Saudi Arabia.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo characterize the use of the drug misoprostol for treatment of postpartum hemorrhage in pregnant women.
methodsA descriptive observational study was carried out with secondary data from pregnant women who used misoprostol to treat postpartum hemorrhage in a reference public maternity, from July 2015 to June 2017. Clinical and sociodemographic profiles of pregnant women, how misoprostol was used and success rate in controling postpartum hemorrhage were characterized.
resultsA total of 717 prescriptions of misoprostol were identified. Of these, 10% were for treatment of postpartum hemorrhage. The majority of pregnant women were young adults, married, with complete high school education, white, residing in urban areas, multiparous (68.1%) and 25% had previous cesarean sections. The mean gestational age was 39 weeks and 51.4% had a cesarean section. There was prophylactic use of oxytocin in 47.2% of women. Treatment of postpartum hemorrhage was successful in 84.7% of women. Of these, 79.2% also used oxytocin and 54.2% methylergonovine. Only 13.5% of pregnant women had less than five prenatal visits, and the main cause of postpartum hemorrhage was uterine atony. There were 13 complications after hemorrhage, 15.3% required blood transfusion and there was one case of maternal death.
conclusionMisoprostol showed to be effective and safe for treating postpartum hemorrhage.
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