Evidence map›Paper›PMID 31721635›Full record

ArticleMolecular biology of the cell2020

EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells.

Irini Topalidou, Jérôme Cattin-Ortolá, Blake Hummer, Cedric S Asensio, Michael Ailion

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Irini TopalidouDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Jérôme Cattin-OrtoláDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Blake HummerDepartment of Biological Sciences, University of Denver, Denver, CO 80210.
Cedric S AsensioDepartment of Biological Sciences, University of Denver, Denver, CO 80210.
Michael AilionDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
University of Washington · USUniversity of Denver · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
NEUROBIOLOGYT32GM007108 · NIGMS · UNIVERSITY OF WASHINGTON · PI BINDER, MARC D · 1985 to 2014
$6.1M
Proteins important for dense-core vesicle functionR01GM121481 · NIGMS · UNIVERSITY OF WASHINGTON · PI AILION, MICHAEL · 2018 to 2022
$1.8M
Formation of the Regulated Secretory Pathway: a View from the CytosolR01GM124035 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI ASENSIO, CEDRIC STEPHANE · 2017 to 2021
$1.5M
Regulation of Synaptic Transmission by GqR00MH082109 · NIMH · UNIVERSITY OF WASHINGTON · PI AILION, MICHAEL · 2011 to 2013
$726k
Cellular Mechanisms Controlling the Formation of Large Dense Core VesiclesR15GM116096 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI ASENSIO, CEDRIC STEPHANE · 2015 to 2015
$360k
NIDDK NIH HHS P30 DK017047NIGMS NIH HHS R01 GM121481NIGMS NIH HHS R01 GM124035NIGMS NIH HHS R15 GM116096NIGMS NIH HHS T32 GM007108NIMH NIH HHS R00 MH082109
6 · The paper itself

Abstract

Dense-core vesicles (DCVs) are secretory vesicles found in neurons and endocrine cells. DCVs package and release cargoes including neuropeptides, biogenic amines, and peptide hormones. We recently identified the endosome-associated recycling protein (EARP) complex and the EARP-interacting-protein EIPR-1 as proteins important for controlling levels of DCV cargoes in

Indexed as

AnimalsBiophysical PhenomenaCaenorhabditis elegansCaenorhabditis elegans ProteinsCarrier ProteinsCell LineEndosomesGolgi ApparatusInsulin-Secreting CellsNeuronsNeuropeptidesProtein TransportSecretory Vesiclestrans-Golgi NetworkVesicular Transport ProteinsCaenorhabditis elegans ProteinsCarrier ProteinsEIPR-1 protein, C elegansNeuropeptidesVesicular Transport Proteins

Identifiers

PMID31721635
PMCPMC6938272
OpenAlexW2987819603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.