Evidence map›Paper›PMID 31721616›Full record

ArticleAmerican journal of physiology. Cell physiology2020

Reactive oxygen species-dependent regulation of pyruvate dehydrogenase kinase-4 in white adipose tissue.

Logan K Townsend, Alyssa J Weber, Pierre-Andre Barbeau, Graham P Holloway, David C Wright

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Oxidative Stress Responses in Obese Individuals Undergoing Bariatric Surgery: Impact on Carcinogenesis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  3. Review
  4. Article
  5. Article
  6. AMPK's double-faced role in advanced stages of prostate cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Logan K TownsendDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.ORCID 0000-0002-4311-2702
Alyssa J WeberDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Pierre-Andre BarbeauDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Graham P HollowayDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
David C WrightDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
University of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) are important signaling molecules mediating the exercise-induced adaptations in skeletal muscle. Acute exercise also drives the expression of genes involved in reesterification and glyceroneogenesis in white adipose tissue (WAT), but whether ROS play any role in this effect has not been explored. We speculated that exercise-induced ROS would regulate acute exercise-induced responses in WAT. To address this question, we utilized various models to alter redox signaling in WAT. We examined basal and exercise-induced gene expression in a genetically modified mouse model of reduced mitochondrial ROS emission [mitochondrial catalase overexpression (MCAT)]. Additionally, H

Indexed as

Energy MetabolismAdipocytesAdipogenesisAdipose Tissue, WhiteAdrenergic beta-3 Receptor AgonistsAnimalsAntioxidantsCatalaseGene Expression Regulation, EnzymologicIntracellular Signaling Peptides and ProteinsMaleMice, Inbred C57BLMice, TransgenicMitochondriaOxidantsOxidation-ReductionAdrenergic beta-3 Receptor AgonistsAntioxidantsCatalaseIntracellular Signaling Peptides and ProteinsOxidantsPck1 protein, mousePdk4 protein, mousePhosphoenolpyruvate Carboxykinase (GTP)Pyruvate Dehydrogenase Acetyl-Transferring KinaseReactive Oxygen Speciesadipose tissueexerciseglyceroneogenesisreactive oxygen speciesreesterification

Identifiers

PMID31721616
PMCPMC6985839
OpenAlexW2983113929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.