Evidence map›Paper›PMID 31721604›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Blockade of endogenous angiotensin II type I receptor agonistic autoantibody activity improves mitochondrial reactive oxygen species and hypertension in a rat model of preeclampsia.

Venkata Ramana Vaka, Mark W Cunningham, Evangeline Deer, Michael Franks, Tarek Ibrahim, Lorena M Amaral, Nathan Usry, Denise C Cornelius, Ralf Dechend, Gerd Wallukat and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 41 citations in OpenAlex.

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  12. Relationship betweenCardiovascular therapeutics · 2023
    Article
  13. Oxidative Regulation of Vascular CaAntioxidants (Basel, Switzerland) · 2022
    Review
  14. Inhibition of the ATAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Venkata Ramana VakaDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Mark W CunninghamDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Evangeline DeerDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Michael FranksDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Tarek IbrahimDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Lorena M AmaralDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Nathan UsryDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Denise C CorneliusDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-6730-6499
Ralf DechendExperimental and Clinical Research Center, HELIOS Clinic, Berlin, Germany.
Gerd WallukatExperimental and Clinical Research Center, Charité Campus Buch, Max-Delbrück Center for Molecular Medicine, Berlin, Germany.
Babbette D LaMarcaDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
University of Mississippi Medical Center · USHelios Hospital Berlin-Buch · DEMax Delbrück Center · DE

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ashley C. Johnson, Babbette LaMarca · 2017 to 2026
$26.4M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
NHLBI NIH HHS T32 HL105324NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Preeclampsia (PE) is characterized by new-onset hypertension that usually occurs in the third trimester of pregnancy and is associated with oxidative stress and angiotensin II type 1 receptor agonistic autoantibodies (AT

Indexed as

AnimalsAntihypertensive AgentsAutoantibodiesBlood PressureCells, CulturedDisease Models, AnimalFemaleHumansHuman Umbilical Vein Endothelial CellsKidneyMitochondriaOxidative StressPeptidesPre-EclampsiaPregnancyRats, Sprague-DawleyAntihypertensive AgentsAutoantibodiesPeptidesReactive Oxygen SpeciesReceptor, Angiotensin, Type 1AT1-AAs and preeclampsiamitochondrial dysfunctionmitochondrial reactive oxygen species

Identifiers

PMID31721604
PMCPMC7052605
OpenAlexW2986696223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.