Evidence map›Paper›PMID 31721480›Full record

ArticleJournal of cachexia, sarcopenia and muscle2020

Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis-associated cachexia.

Wai W Cheung, Sheng Hao, Zhen Wang, Wei Ding, Ronghao Zheng, Alex Gonzalez, Jian-Ying Zhan, Ping Zhou, Shiping Li, Mary C Esparza and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Cancer cachexia: molecular basis and therapeutic advances.Signal transduction and targeted therapy · 2026
    Review
  5. Cystinosis and Cellular Energy Failure: Mitochondria at the Crossroads.International journal of molecular sciences · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. The Atrophic Effect of 1,25(OH)Antioxidants (Basel, Switzerland) · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Wai W CheungPediatric Nephrology, Rady Children's Hospital-San Diego, University of California, San Diego, San Diego, CA, USA.
Sheng HaoDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhen WangDepartment of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Wei DingDivision of Nephrology, Shanghai 9th People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Ronghao ZhengDepartment of Pediatric Nephrology, Rheumatology, and Immunology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Alex GonzalezPediatric Nephrology, Rady Children's Hospital-San Diego, University of California, San Diego, San Diego, CA, USA.
Jian-Ying ZhanChildren's Hospital, Zhejiang University, Hangzhou, China.
Ping ZhouDepartment of Pediatrics, The 2nd Hospital of Harbin Medical University, Harbin, China.
Shiping LiCollege of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.
Mary C EsparzaDepartment of Orthopedic Surgery, University of California, San Diego, San Diego, CA, USA.
Hal M HoffmanDepartment of Pediatrics, University of California, San Diego, San Diego, CA, USA.
Richard L LieberDepartment of Orthopedic Surgery, University of California, San Diego, San Diego, CA, USA.
Robert H MakPediatric Nephrology, Rady Children's Hospital-San Diego, University of California, San Diego, San Diego, CA, USA.
University of California, San Diego · USUniversity of San Diego · USBoston Children's Hospital · USHarbin Medical University · CNShanghai Children's Hospital · CNShanghai First People's Hospital · CNShanghai Ninth People's Hospital · CNWuhan Children's Hospital · CNYangzhou University · CN

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
National Center for Muscle Rehabilitation ResearchR24HD050837 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIEBER, RICHARD L., WARD, SAMUEL RICHARD · 2005 to 2014
$7.2M
NCATS NIH HHS UL1 TR001422NICHD NIH HHS R24 HD050837
6 · The paper itself

Abstract

backgroundCtns

methodsTwelve-month-old Ctns

resultsSupplementation of 25(OH)D

conclusionsWe report the novel findings that correction of 25(OH)D

Indexed as

Adipose Tissue, BrownAnimalsCachexiaCystinosisDisease Models, AnimalFemaleHumansMaleMiceMuscle, SkeletalMuscular AtrophyVitamin DVitamin DAdipose tissue browningCachexiaInfantile nephropathic cystinosisMuscle wastingVitamin D insufficiency

Identifiers

PMID31721480
PMCPMC7015252
OpenAlexW2983494741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.