ArticleAnnals of clinical and translational neurology2019
Study partner-reported decline identifies cognitive decline and dementia risk.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
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Who cites it
27 citing papers in PubMed.
- Association of the Informant-Reported Memory Decline With Cognitive and Brain Deterioration Through the Alzheimer Clinical Continuum.Neurology · 2023Trial
- AI-Driven Digital Twin Architecture for Multimodal Prediction and Adaptive Intervention in Cognitive Aging.JMIR AI · 2026Article
- Evaluating self- and informant-reported complaints as predictors of cognitive progression in subjective cognitive decline: A clinically-based evaluation.Journal of Alzheimer's disease : JAD · 2026Article
- Clinical definition, biological characterization, and detection guidelines of subjective cognitive decline due to Alzheimer's disease and related dementia: A position paper from ISTAART SCD PIA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Study partners' views on remuneration in longitudinal Alzheimer's disease research.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Predictors of transitions between normal cognition, cognitive impairment, and dementia in a longitudinal cohort.Journal of Alzheimer's disease : JAD · 2025Article
- Validation of the standard assessment of global everyday activities (SAGEA) scale for dementia diagnosis.Age and ageing · 2025Article
- Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis.JAMA network open · 2025Observational
- Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry.Alzheimer's research & therapy · 2025Article
- A short version of the Everyday Cognition scale can predict clinical progression and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cognitive performance in patients with neuromyelitis optica: clinical and imaging characteristics.Scientific reports · 2024Article
- Clinical importance in Alzheimer's disease: effects of anchor agreement and disease severity.Aging clinical and experimental research · 2024Article
- Self- and interviewer-reported cognitive problems in relation to cognitive decline and dementia: results from two prospective studies.BMC medicine · 2024Article
- Performance of a Short Version of the Everyday Cognition Scale (ECog-12) to Detect Cognitive Impairment.The journal of prevention of Alzheimer's disease · 2024Article
- Predicting Amyloid-β Positivity in Alzheimer's Disease: Comprehensive Analysis of Feature Selection and Machine Learning Models for Accurate Identification.International journal of online and biomedical engineering · 2023Article
- Examining the role of participant and study partner report in widely-used classification approaches of mild cognitive impairment in demographically-diverse community dwelling individuals: results from the Einstein aging study.Frontiers in aging neuroscience · 2023Article
- Retention of Study Partners in Longitudinal Studies of Alzheimer Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- The role of dyadic cognitive report and subjective cognitive decline in early ADRD clinical research and trials: Current knowledge, gaps, and recommendations.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Everyday Functioning and Entorhinal and Inferior Temporal Tau Burden in Cognitively Normal Older Adults.The journal of prevention of Alzheimer's disease · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveIdentifying individuals at risk for cognitive decline, Mild Cognitive Impairment (MCI), and dementia due to Alzheimer's disease (AD) is a critical need. Functional decline is associated with risk and can be efficiently assessed by participants and study partners (SPs). We tested the hypothesis that SP-reported functional decline is an independent predictor of dementia risk and cognitive decline.
methodsIn 1048 older adults in the Alzheimer's Disease Neuroimaging Initiative (ADNI), we measured associations between Everyday Cognition Scale scores (ECog, self- and SP-reported versions) and (1) baseline and longitudinal change in neuropsychological test (NPT scores) across multiple cognitive domains; (2) diagnostic conversion to MCI or dementia. Models included Mini Mental Status Exam (MMSE) score and ApoE ε4 genotype (APOE) as predictors. Model fits were compared with and without predictors of interest included.
resultsSP-reported ECog was the strongest predictor of cognitive decline across multiple domains, as well as diagnostic conversion. Self-reported ECog was associated with baseline NPT scores in some cognitive domains, and diagnostic conversion to MCI in participants with biomarker evidence for AD (elevated brain β-amyloid, Aβ). Models including SP-reported ECog were significantly stronger at predicting outcomes.
conclusionsSP-reported functional decline is an independent indicator of cognitive decline and dementia risk, even when accounting for cognitive screening, genetic risk, demographics, and self-report decline. The results provide a rationale for greater utilization of SP-reported functional decline to identify those at risk for dementia due to AD and other causes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.