Evidence map›Paper›PMID 31721409›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

IL-22 is required for the induction of bronchus-associated lymphoid tissue in tolerant lung allografts.

Satona Tanaka, Jason M Gauthier, Anja Fuchs, Wenjun Li, Alice Y Tong, Margaret S Harrison, Ryuji Higashikubo, Yuriko Terada, Ramsey R Hachem, Daniel Ruiz-Perez and 7 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Multi-site cytokine levels are predictive of primary graft dysfunction following lung transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  2. Tolerogenic lung allograft microenvironment suppresses pathogenic tissue remodeling following respiratory virus infection in mice.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  3. Review
  4. Review
  5. Science translational medicine · 2025
    Article
  6. Review
  7. Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Ischemia reperfusion injury facilitates lung allograft acceptance through IL-33-mediated activation of donor-derived IL-5 producing group 2 innate lymphoid cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  13. Review
  14. Article
  15. Review
  16. EfficientFrontiers in immunology · 2021
    Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Satona TanakaDivision of Cardiothoracic Surgery, Washington University, Saint Louis, Missouri, USA.
Jason M GauthierDivision of Cardiothoracic Surgery, Washington University, Saint Louis, Missouri, USA.
Anja FuchsSection of Acute and Critical Care Surgery, Department of Surgery, Washington University, Saint Louis, Missouri, USA.
Wenjun LiDivision of Cardiothoracic Surgery, Washington University, Saint Louis, Missouri, USA.
Alice Y TongDivision of Cardiothoracic Surgery, Washington University, Saint Louis, Missouri, USA.
Margaret S HarrisonDivision of Cardiothoracic Surgery, Washington University, Saint Louis, Missouri, USA.
Ryuji HigashikuboDivision of Cardiothoracic Surgery, Washington University, Saint Louis, Missouri, USA.
Yuriko TeradaDivision of Cardiothoracic Surgery, Washington University, Saint Louis, Missouri, USA.
Ramsey R HachemDepartment of Medicine, Washington University, Saint Louis, Missouri, USA.
Daniel Ruiz-PerezDivision of Experimental Surgery, La Paz University Hospital, Madrid, Spain.
Jon H RitterDepartment of Pathology & Immunology, Washington University, Saint Louis, Missouri, USA.
Marina CellaDepartment of Pathology & Immunology, Washington University, Saint Louis, Missouri, USA.
Marco ColonnaDepartment of Pathology & Immunology, Washington University, Saint Louis, Missouri, USA.
Isaiah R TurnbullSection of Acute and Critical Care Surgery, Department of Surgery, Washington University, Saint Louis, Missouri, USA.
Alexander S KrupnickDivision of Thoracic Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-1790-6197
Andrew E GelmanDivision of Cardiothoracic Surgery, Washington University, Saint Louis, Missouri, USA.ORCID 0000-0002-0711-6343
Daniel KreiselDivision of Cardiothoracic Surgery, Washington University, Saint Louis, Missouri, USA.ORCID 0000-0002-7711-8651
Washington University in St. Louis · USCarter Center · USHospital Universitario La Paz · ES

Funding

The Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI Daniel Kreisel · 2015 to 2026
$19.4M
THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9M
Hematopoietic Stem and Progenitor Cell Dysfunction is an Underlying Mechanism of Injury-Inuced ImmunosuppressionR35GM133756 · NIGMS · WASHINGTON UNIVERSITY · PI TURNBULL, ISAIAH R · 2019 to 2023
$2.0M
Innate Immune Mechanisms of Ischemia Reperfusion Injury Following Cardiac TransplantationF32HL143950 · NHLBI · WASHINGTON UNIVERSITY · PI GAUTHIER, JASON MICHAEL · 2018 to 2018
$60k
Leukocyte trafficking in thoracic graftsI01BX002730 · VA · ST. LOUIS VA MEDICAL CENTER · PI KREISEL, DANIEL · 2016 to 2025
–
BLRD VA I01 BX002730NHLBI NIH HHS F32 HL143950NHLBI NIH HHS R01 HL094601NIAID NIH HHS P01 AI116501NIGMS NIH HHS R35 GM133756
6 · The paper itself

Abstract

Long-term survival after lung transplantation remains profoundly limited by graft rejection. Recent work has shown that bronchus-associated lymphoid tissue (BALT), characterized by the development of peripheral nodal addressin (PNAd)-expressing high endothelial venules and enriched in B and Foxp3

Indexed as

Immunity, InnateLymphoid TissueAllograftsBronchiGraft RejectionHumansInterleukin-22InterleukinsLungLymphocytesInterleukin-22Interleukinsanimal models: murinebasic (laboratory) research/scienceimmunobiologylung transplantation/pulmonologylymph nodelymphocyte biologytolerance: experimental

Identifiers

PMID31721409
PMCPMC7183893
OpenAlexW2987394347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.