ArticleHuman brain mapping2020
Hubs disruption in mesial temporal lobe epilepsy. A resting-state fMRI study on a language-and-memory network.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy.Frontiers in neurology · 2022Pooled it
- Review
- Illness Perception and Psychosocial Adjustment in Brain Tumor Patients and Their Family Caregivers: An Actor-Partner Interdependence Model Analysis.Cancer medicine · 2026Article
- Abnormal functional connectivity patterns in temporal lobe epilepsy-An international ENIGMA-epilepsy study.Epilepsia open · 2026Article
- Impact of ictal spread on preoperative memory and language functions and postoperative seizure outcomes in drug-resistant epilepsy.Epilepsy & behavior : E&B · 2025Article
- Language and Memory Network Alterations in Temporal Lobe Epilepsy: A Functional and Structural Connectivity Study.AJNR. American journal of neuroradiology · 2025Article
- Mapping human thalamocortical connectivity with electrical stimulation and recording.Nature neuroscience · 2025Article
- Individualized Functional and Structural Language Lateralities in Temporal Lobe Epilepsy and Their Impact on Memory.Human brain mapping · 2025Article
- Structural signatures of language reorganization after left hemispherotomy in patients with Rasmussen's encephalitis.Brain structure & function · 2025Article
- Neural (re)organisation of language and memory: implications for neuroplasticity and cognition.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- How Can Graph Theory Inform the Dual-stream Model of Speech Processing? A Resting-state Functional Magnetic Resonance Imaging Study of Stroke and Aphasia Symptomology.Journal of cognitive neuroscience · 2025Article
- When age tips the balance: A dual mechanism affecting hemispheric specialization for language.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Identifying novel data-driven subgroups in congenital heart disease using multi-modal measures of brain structure.NeuroImage · 2024Article
- Causal Cortical and Thalamic Connections in the Human Brain.bioRxiv : the preprint server for biology · 2024Article
- Unveiling the cognitive network organization through cognitive performance.Scientific reports · 2024Article
- Modeling the neurocognitive dynamics of language across the lifespan.Human brain mapping · 2024Article
- Hub overload and failure as a final common pathway in neurological brain network disorders.Network neuroscience (Cambridge, Mass.) · 2024Review
- When Age Tips the Balance: a Dual Mechanism Affecting Hemispheric Specialization for Language.bioRxiv : the preprint server for biology · 2023Article
- Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study.Scientific reports · 2023Article
- Altered structural connectome of children with auditory processing disorder: a diffusion MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesial temporal lobe epilepsy (mTLE) affects the brain networks at several levels and patients suffering from mTLE experience cognitive impairment for language and memory. Considering the importance of language and memory reorganization in this condition, the present study explores changes of the embedded language-and-memory network (LMN) in terms of functional connectivity (FC) at rest, as measured with functional MRI. We also evaluate the cognitive efficiency of the reorganization, that is, whether or not the reorganizations support or allow the maintenance of optimal cognitive functioning despite the seizure-related damage. Data from 37 patients presenting unifocal mTLE were analyzed and compared to 48 healthy volunteers in terms of LMN-FC using two methods: pairwise correlations (region of interest [ROI]-to-ROI) and graph theory. The cognitive efficiency of the LMN-FC reorganization was measured using correlations between FC parameters and language and memory scores. Our findings revealed a large perturbation of the LMN hubs in patients. We observed a hyperconnectivity of limbic areas near the dysfunctional hippocampus and mainly a hypoconnectivity for several cortical regions remote from the dysfunctional hippocampus. The loss of FC was more important in left mTLE (L-mTLE) than in right (R-mTLE) patients. The LMN-FC reorganization may not be always compensatory and not always useful for patients as it may be associated with lower cognitive performance. We discuss the different connectivity patterns obtained and conclude that interpretation of FC changes in relation to neuropsychological scores is important to determine cognitive efficiency, suggesting the concept of "connectome" would gain to be associated with a "cognitome" concept.
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