ArticleJournal of clinical laboratory analysis2020
Reduced expression of circRNA hsa_circ_0067582 in human gastric cancer and its potential diagnostic values.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Appraising circular RNAs as novel biomarkers for the diagnosis and prognosis of gastric cancer: A pair-wise meta-analysis.Journal of clinical laboratory analysis · 2020Pooled it
- The potential of circular RNAs as biomarkers and therapeutic targets for gastric cancer: A comprehensive review.Journal of advanced research · 2025Review
- Serum hsa_circ_0000615 is a prognostic biomarker of sorafenib resistance in hepatocellular carcinoma.Journal of clinical laboratory analysis · 2022Article
- Hsa_circ_0001020 Serves as a Potential Biomarker for Gastric Cancer Screening and Prognosis.Digestive diseases and sciences · 2022Article
- Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs.Journal of periodontal research · 2022Article
- Hsa_circ_0003195 as a biomarker for diagnosis and prognosis of gastric cancer.International journal of clinical oncology · 2022Article
- CircRNAs as Potential Blood Biomarkers and Key Elements in Regulatory Networks in Gastric Cancer.International journal of molecular sciences · 2022Article
- The expression profile and clinical application value of hsa_circ_0016148 in head and neck squamous cell carcinoma.Journal of clinical laboratory analysis · 2021Article
- Integrated study of circRNA, lncRNA, miRNA, and mRNA networks in mediating the effects of testicular heat exposure.Cell and tissue research · 2021Article
- Down-regulation of hsa_circ_0006470 predicts tumor invasion: A new biomarker of gastric cancer.Journal of clinical laboratory analysis · 2021Article
- The role of circRNA derived from RUNX2 in the serum of osteoarthritis and its clinical value.Journal of clinical laboratory analysis · 2021Article
- Circular RNA hsa_circ_0001874 is an indicator for gastric cancer.Journal of clinical laboratory analysis · 2021Article
- Tumor suppressor role of hsa_circ_0035445 in gastric cancer.Journal of clinical laboratory analysis · 2021Article
- Low expression of hsa_circ_0001811 in gastric cancer and its role in clinical diagnosis.Journal of clinical laboratory analysis · 2021Article
- CircCSNK1G1 Contributes to the Tumorigenesis of Gastric Cancer by Sponging miR-758 and Regulating ZNF217 Expression.Cancer management and research · 2021Article
- Global profile of tRNA-derived small RNAs in gastric cancer patient plasma and identification of tRF-33-P4R8YP9LON4VDP as a new tumor suppressor.International journal of medical sciences · 2021Article
- Clinical diagnostic values of transfer RNA-derived fragment tRF-19-3L7L73JD and its effects on the growth of gastric cancer cells.Journal of Cancer · 2021Article
- Hints From the Cellular Functions to the Practical Outlook of Circular RNAs.Frontiers in genetics · 2021Review
- Research progress of circular RNA in digestive tract tumors: a narrative review.Translational cancer research · 2020Review
- CircHN1 affects cell proliferation and migration in gastric cancer.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Circular RNAs (circRNAs) are an abundant kind of endogenous RNAs that recently are found play a crucial role in the cancer occurrence and development. Nevertheless, little is known with regard to the diagnostic values of these circRNAs for GC. In this article of research, we investigated the role of hsa_circ_0067582 in clinical diagnosis of GC. MATERIALS AND
methodsWe used divergent primers, and the expression levels of hsa_circ_0067582 in 93 fresh GC tissues and paired adjacent normal tissues from surgical patients were detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Then, a receiver operating characteristic (ROC) curve was established to assess the diagnostic significance of hsa_circ_0067582. The relationship between expression of hsa_circ_0067582 and clinicopathological factors of patients was made further explored.
resultsHsa_circ_0067582 levels were significantly decreased in GC tissues contrasted with adjacent normal tissues (n = 93, P < .001). After that, we discovered that it was evidently downregulated in 81.7% (76/93) GC tissues. The area under the ROC curve (AUC) of hsa_circ_0067582 was up to 0.6937, the sensitivity was 66.67%, and the specificity was 61.29%. Moreover, the hsa_circ_0067582 levels were obviously associated with tumor diameter (P = .002) and carbohydrate antigen 19-9 (CA19-9, P = .01). Meanwhile, after operation, low-level group of hsa_circ_0067582 of GC patients was associated with better prognosis.
conclusionOur data imply that hsa_circ_000067582 may be a potential biomarker for GC diagnosis and prognosis evaluation.
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