Evidence map›Paper›PMID 31721288›Full record

ArticleJournal of veterinary internal medicine2020

Lower urinary tract transitional cell carcinoma in cats: Clinical findings, treatments, and outcomes in 118 cases.

Maureen A Griffin, William T N Culp, Michelle A Giuffrida, Peter Ellis, Joanne Tuohy, James A Perry, Allison Gedney, Cassie N Lux, Milan Milovancev, Mandy L Wallace and 12 more

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Guideline
  2. Urothelial Carcinoma in a Cat with Bilateral Ectopic Ureters.Animals : an open access journal from MDPI · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 10 institutions in 2 countries.

Maureen A GriffinSchool of Veterinary Medicine, University of California-Davis, Davis, California.
William T N CulpSchool of Veterinary Medicine, University of California-Davis, Davis, California.ORCID https://orcid.org/0000-0001-6132-156X
Michelle A GiuffridaSchool of Veterinary Medicine, University of California-Davis, Davis, California.
Peter EllisSchool of Veterinary Medicine, University of California-Davis, Davis, California.
Joanne TuohyCollege of Veterinary Medicine, Colorado State University, Fort Collins, Colorado.
James A PerrySchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Allison GedneySchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Cassie N LuxCollege of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee.
Milan MilovancevCarlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon.
Mandy L WallaceCollege of Veterinary Medicine, University of Georgia, Athens, Georgia.
Jonathan HashCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.
Kyle MathewsCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.ORCID https://orcid.org/0000-0003-3431-6049
Julius M LiptakVCA Canada-Alta Vista Animal Hospital, Ottawa, Ontario, Canada.
Laura E SelmicCollege of Veterinary Medicine, University of Illinois, Urbana, Illinois.
Ameet SinghOntario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Carrie A PalmSchool of Veterinary Medicine, University of California-Davis, Davis, California.ORCID https://orcid.org/0000-0003-1445-5113
Ingrid M BalsaSchool of Veterinary Medicine, University of California-Davis, Davis, California.
Philipp D MayhewSchool of Veterinary Medicine, University of California-Davis, Davis, California.
Michele A SteffeySchool of Veterinary Medicine, University of California-Davis, Davis, California.
Robert B RebhunSchool of Veterinary Medicine, University of California-Davis, Davis, California.
Jenna H BurtonSchool of Veterinary Medicine, University of California-Davis, Davis, California.
Michael S KentSchool of Veterinary Medicine, University of California-Davis, Davis, California.
University of California, Davis · USNorth Carolina State University · USUniversity of Pennsylvania · USColorado State University · USKnoxville College · USOregon State University · USOttawa Hospital · CAUniversity of Georgia · USUniversity of Guelph · CAUniversity of Illinois Urbana-Champaign · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9M
NCI NIH HHS P30 CA093373
6 · The paper itself

Abstract

backgroundLower urinary tract transitional cell carcinoma (TCC) is an important but rarely described disease of cats.

objectivesTo report the clinical characteristics, treatments, and outcomes in a cohort of cats with lower urinary tract TCC and to test identified variables for prognostic relevance. ANIMALS: One-hundred eighteen client-owned cats with lower urinary tract carcinoma.

methodsMedical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes. Recorded variables were analyzed statistically.

resultsMedian age of affected cats was 15 years (range, 5.0-20.8 years) and median duration of clinical signs was 30 days (range, 0-730 days). The trigone was the most common tumor location (32/118; 27.1%) as assessed by ultrasound examination, cystoscopy, or both. Treatment was carried out in 73 of 118 (61.9%) cats. Metastatic disease was documented in 25 of 118 (21.2%) cats. Median progression-free survival and survival time for all cats were 113 days (95% confidence interval [CI], 69-153) and 155 days (95% CI, 110-222), respectively. Survival increased significantly (P < .001) when comparing cats across the ordered treatment groups: no treatment, treatment without partial cystectomy, and treatment with partial cystectomy. Partial cystectomy (hazard ratio [HR], 0.31; 95% CI, 0.17-0.87) and treatment with nonsteroidal anti-inflammatory drugs (HR, 0.55; 95% CI, 0.33-0.93) were significantly associated with longer survival times. CONCLUSIONS AND CLINICAL IMPORTANCE: The results support treatment using partial cystectomy and NSAIDs in cats with TCC.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCarcinoma, Transitional CellCat DiseasesCatsCohort StudiesCystectomyRetrospective StudiesTreatment OutcomeUrinary Bladder NeoplasmsAnti-Inflammatory Agents, Non-Steroidalbladdercatcystectomyneoplasiaurethra

Identifiers

PMID31721288
PMCPMC6979092
OpenAlexW2988303568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.