Evidence map›Paper›PMID 31721278›Full record

ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2020

Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease.

Deepak A Kaji, Zhijia Tan, Gemma L Johnson, Wesley Huang, Kaetlin Vasquez, Jessica A Lehoczky, Benjamin Levi, Kathryn S E Cheah, Alice H Huang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Deepak A KajiDepartment of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York.
Zhijia TanSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong.
Gemma L JohnsonDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0001-7101-6876
Wesley HuangDepartment of Plastic Surgery, University of Michigan, Ann Arbor, Michigan.
Kaetlin VasquezDepartment of Plastic Surgery, University of Michigan, Ann Arbor, Michigan.
Jessica A LehoczkyDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-9210-2922
Benjamin LeviDepartment of Plastic Surgery, University of Michigan, Ann Arbor, Michigan.
Kathryn S E CheahSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong.
Alice H HuangDepartment of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-5037-6829

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Mechanisms of TGFbeta and Smad signaling in tendon regeneration and fibrosisR01AR069537 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HUANG, ALICE H · 2016 to 2020
$2.1M
Targeting Molecular and Cellular Mediators of Inflammation to Prevent Pathologic Cell Differentiation and Heterotopic OssificationR01AR071379 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2021
$1.5M
TRANSLATING NEW INSIGHTS FROM AXOLOTL LIMB REGENERATION INTO MICER21HD097405 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI LEHOCZKY, JESSICA A, WHITED, JESSICA L. · 2019 to 2020
$480k
Investigation into establishing morphology during mouse digit tip regeneration, in the context of vertebrate limb developmentR03HD093922 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI LEHOCZKY, JESSICA A · 2018 to 2019
$176k
Molecular mechanisms regulating tendon regeneration and tendon cell fateF31AR073626 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KAJI, DEEPAK · 2019 to 2019
$45k
NIAMS NIH HHS F31 AR073626NIAMS NIH HHS R01 AR069537NIAMS NIH HHS R01 AR071379NICHD NIH HHS R03 HD093922NICHD NIH HHS R21 HD097405NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

In this review, we highlight themes from a recent workshop focused on "Plasticity of Cell Fate in Musculoskeletal Tissues" held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:708-718, 2020.

Indexed as

Cell PlasticityMusculoskeletal DevelopmentAnimalsCell DifferentiationDiseaseHumansMyositis OssificansOssification, HeterotopicRegenerationWounds and Injuriesheterotopic ossificationmesenchymal plasticitymusculoskeletal developmentregenerationtransdifferentiation

Identifiers

PMID31721278
PMCPMC7213644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.