Evidence map›Paper›PMID 31721249›Full record

Trial reportClinical cardiology2020

Lower urine sodium predicts longer length of stay in acute heart failure patients: Insights from the ROSE AHF trial.

Jonathan W Cunningham, Jie-Lena Sun, Finnian R Mc Causland, Samantha Ly, Kevin J Anstrom, Joann Lindenfeld, Michael M Givertz, Lynne W Stevenson, Neal K Lakdawala

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. The value of urinary sodium assessment in acute heart failure.European heart journal. Acute cardiovascular care · 2021
    Pooled it
  3. Trial
  4. Article
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  9. The role of urine sodium in acutely decompensated heart failure.International journal of cardiology. Heart & vasculature · 2024
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jonathan W CunninghamCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.ORCID https://orcid.org/0000-0003-4481-7867
Jie-Lena SunDuke Clinical Research Institute, Duke University, Durham, North Carolina.
Finnian R Mc CauslandRenal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Samantha LyRenal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Kevin J AnstromDuke Clinical Research Institute, Duke University, Durham, North Carolina.
Joann LindenfeldVanderbilt University Medical Center, Nashville, Tennessee.
Michael M GivertzCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.ORCID https://orcid.org/0000-0003-1012-7710
Lynne W StevensonVanderbilt University Medical Center, Nashville, Tennessee.
Neal K LakdawalaCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Brigham and Women's Hospital · USDuke University · USVanderbilt University Medical Center · US

Funding

Heart Failure Clinical Research Network Coordinating CenterU10HL084904 · NHLBI · DUKE UNIVERSITY · PI ANSTROM, KEVIN J, HERNANDEZ, ADRIAN · 2012 to 2018
$38.0M
Mayo Heart Failure Regional Clinical CenterU10HL110262 · NHLBI · MAYO CLINIC ROCHESTER · PI REDFIELD, MARGARET M · 2012 to 2018
$3.6M
Heart Failure Clinical Research Network Regional Clinical Center (U10)U10HL110312 · NHLBI · DUKE UNIVERSITY · PI FELKER, GARY M · 2012 to 2018
$3.5M
SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial)U10HL110309 · NHLBI · WASHINGTON UNIVERSITY · PI DAVILA-ROMAN, VICTOR G., MANN, DOUGLAS L · 2012 to 2018
$3.5M
Harvard Regional Clinical Center of the NHLBI Heart Failure NetworkU10HL110337 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GIVERTZ, MICHAEL M, LEWIS, GREGORY DYER · 2012 to 2018
$3.5M
Renal Sympathetic Denervation in Congestive Heart FailureU10HL110336 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI STARLING, RANDALL CARSON, TANG, WAI HONG WILSON · 2012 to 2018
$2.5M
Heart Failure Clinical Trials NetworkU10HL110302 · NHLBI · EMORY UNIVERSITY · PI SMITH, ANDREW · 2012 to 2018
$2.5M
Mid Atlantic Heart Failure NetworkU10HL110338 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, THOMAS P., MARGULIES, KENNETH BER · 2012 to 2018
$2.4M
New England, New York and Quebec Regional Clinical CenterU10HL110342 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUGGINS, GORDON S, VANBUREN, PETER C · 2012 to 2018
$2.3M
The Jefferson Regional Clinical Center for Heart Failure NetworkU10HL110297 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI WHELLAN, DAVID J · 2012 to 2018
$2.0M
The Texas Medical Center Regional Coordinating Center for Heart FailureU01HL084890 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI DESWAL, ANITA · 2006 to 2011
$1.8M
Gene- and Cell-based therapies for LVAD patientsU01HL084889 · NHLBI · UNIVERSITY OF UTAH · PI BULL, DAVID ANDREW · 2006 to 2011
$1.8M
NHLBI NIH HHS Coordinating Center: U10 HL084904NHLBI NIH HHS U01 HL084861NHLBI NIH HHS U01 HL084889NHLBI NIH HHS U01 HL084890NHLBI NIH HHS U01HL084890NHLBI NIH HHS U01 HL084891NHLBI NIH HHS U01 HL084931NHLBI NIH HHS U109 HL110337NHLBI NIH HHS U10 HL084904NHLBI NIH HHS U10 HL110262NHLBI NIH HHS U10 HL110297NHLBI NIH HHS U10 HL110302NHLBI NIH HHS U10 HL110309NHLBI NIH HHS U10 HL110312NHLBI NIH HHS U10 HL110336NHLBI NIH HHS U10 HL110337NHLBI NIH HHS U10 HL110338NHLBI NIH HHS U10 HL110342NIDDK NIH HHS R03 DK122240
6 · The paper itself

Abstract

backgroundIn patients hospitalized with acute heart failure (AHF), low urine sodium concentration (U

methodsThe Renal Optimization Strategies Evaluation AHF (ROSE AHF) trial randomized 360 patients with AHF and renal dysfunction receiving intravenous diuretic to dopamine, nesiritide, or placebo. Sodium concentration was measured in cumulative urine sample collected during the first 24 hours after randomization in 298 patients. Based on prior studies, lower U

resultsLower U

conclusionIn patients hospitalized for AHF and renal dysfunction, U

Indexed as

Acute DiseaseAgedAged, 80 and overDiureticsFemaleHeart FailureHumansLength of StayMaleMiddle AgedPrognosisRenal InsufficiencyRisk FactorsSodiumUnited StatesDiureticsSodiumclinical pharmacologyclinical trialsheart failurekidney disease

Identifiers

PMID31721249
PMCPMC6954375
OpenAlexW2984250378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.