ArticleThe Journal of comparative neurology2020
Increased density and age-related sharing of synapses at the cone to OFF bipolar cell synapse in the mouse retina.
Article in The Journal of comparative neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- A suite of engineered mice for interrogating psychedelic drug actions.bioRxiv : the preprint server for biology · 2023Article
- Cell numbers, cell ratios, and developmental plasticity in the rod pathway of the mouse retina.Journal of anatomy · 2023Review
- Student remote and distance research in neuroanatomy: Mapping Dscaml1 expression with a LacZ gene trap in mouse brain.Anatomia, histologia, embryologia · 2023Article
- Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse.Investigative ophthalmology & visual science · 2022Article
- OFF bipolar cell density varies by subtype, eccentricity, and along the dorsal ventral axis in the mouse retina.The Journal of comparative neurology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Neural circuits in the adult nervous system are characterized by stable, cell type-specific patterns of synaptic connectivity. In many parts of the nervous system these patterns are established during development through initial over-innervation by multiple pre- or postsynaptic targets, followed by a process of refinement that takes place during development and is in many instances activity dependent. Here we report on an identified synapse in the mouse retina, the cone photoreceptor➔type 4 bipolar cell (BC4) synapse, and show that its development is distinctly different from the common motif of over-innervation followed by refinement. Indeed, the majority of cones are contacted by single BC4 throughout development, but are contacted by multiple BC4s through ongoing dendritic elaboration between 1 and 6 months of age-well into maturity. We demonstrate that cell density drives contact patterns downstream of single cones in Bax null mice and may serve to maintain constancy in both the dendritic and axonal projective field.
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Registered trials
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