Evidence map›Paper›PMID 31721082›Full record

ArticleJournal of neurovirology2020

The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda.

Violet Awori, Gertrude Nakigozi, Alice Kisakye, James Batte, Aggrey Anok, Richard Mayanja, Noeline Nakasujja, Kevin R Robertson, Ronald H Gray, Maria J Wawer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Violet AworiAga Khan University Hospital, Nairobi, Kenya.
Gertrude NakigoziRakai Health Sciences Program, Kalisizo, Uganda.
Alice KisakyeRakai Health Sciences Program, Kalisizo, Uganda.
James BatteRakai Health Sciences Program, Kalisizo, Uganda.
Aggrey AnokRakai Health Sciences Program, Kalisizo, Uganda.
Richard MayanjaRakai Health Sciences Program, Kalisizo, Uganda.
Noeline NakasujjaDepartment of Psychiatry, Makerere University, Kampala, Uganda.
Kevin R RobertsonDepartment of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Ronald H GrayDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Maria J WawerDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Ned SacktorDepartment of Neurology, Johns Hopkins University School of Medicine, Meyer 6-113, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Deanna SaylorDepartment of Neurology, Johns Hopkins University School of Medicine, Meyer 6-113, 600 N. Wolfe Street, Baltimore, MD, 21287, USA. deanna@jhmi.edu.ORCID 0000-0002-9297-0244

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Barbara Stauch Slusher · 2006 to 2026
$33.2M
Research Education Program for Residents and Fellows in Neurology - PorrasR25NS065729 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2009 to 2024
$3.3M
Neurologic Sequelae of HIV Subtype A and D Infection and ART Rakai UgandaR01MH099733 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SACKTOR, NED C, WAWER, MARIA J · 2013 to 2017
$3.0M
Translational Research in Neuro-AIDS and Mental HealthR25MH080661 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MCARTHUR, JUSTIN CHARLES. · 2007 to 2019
$2.9M
Mental Health and Cognition in HIV Infection in Rakai UgandaR01MH120693 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PAUL, ROBERT HARRIS, RUBIN, LEAH HELANE · 2019 to 2023
$2.9M
National Institute of Allergy and Infectious Diseases P30AI094189-01A1NIAID NIH HHS P30 AI094189NIMH NIH HHS MH075673NIMH NIH HHS MH080661-08NIMH NIH HHS MH099733NIMH NIH HHS P30 MH075673NIMH NIH HHS R01 MH099733NIMH NIH HHS R01 MH120693NIMH NIH HHS R25 MH080661NINDS NIH HHS L30 NS088658NINDS NIH HHS L30NS088658NINDS NIH HHS NS065729-05S2NINDS NIH HHS R25 NS065729
6 · The paper itself

Abstract

The Veterans Aging Cohort Study (VACS) Index has been associated with HIV-associated neurocognitive disorder (HAND) in some populations but has not been studied in sub-Saharan Africa. We investigated whether the VACS Index is associated with HAND in a rural population in Rakai, Uganda. HIV-infected (HIV+) adults on antiretroviral therapy underwent a neurocognitive battery for determination of HAND stage using Frascati criteria. VACS component scores were recorded for all participants. Out of 156 study participants, HAND stages were 49% normal cognition, 15% asymptomatic neurocognitive impairment, 31% minor neurocognitive disorder, and 7% HIV-associated dementia. There was no significant association between VACS Index and any HAND stage. In this first study of the VACS Index in sub-Saharan Africa, we found no association between VACS Index score and HAND.

Indexed as

Severity of Illness IndexAdultAIDS Dementia ComplexCohort StudiesFemaleHumansMaleUgandaVeteransGlobal healthHIVHIV-associated neurocognitive disorderUgandaVeterans aging cohort study index

Identifiers

PMID31721082
PMCPMC8012007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.