Evidence map›Paper›PMID 31721070›Full record

ArticleClinical drug investigation2020

Safety, Tolerability, and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis.

Carla Cristina Souza Gomez, Paloma Lopes Francisco Parazzi, Karl Jan Clinckspoor, Renan Marrichi Mauch, Francisco Benedito Teixeira Pessine, Carlos Emilio Levy, Andressa Oliveira Peixoto, Maria Ângela Gonçalves Oliveira Ribeiro, Antônio Fernando Ribeiro, Douglas Conrad and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical drug investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  13. The therapeutic importance of acid-base balance.Biochemical pharmacology · 2021
    Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Carla Cristina Souza GomezCenter for Investigation in Pediatrics, Department of Pediatrics, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 126, Tessália Vieira de Camargo, Campinas, São Paulo, 13083-887, Brazil. carlacg.gomez@gmail.com.
Paloma Lopes Francisco ParazziCenter for Investigation in Pediatrics, Department of Pediatrics, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 126, Tessália Vieira de Camargo, Campinas, São Paulo, 13083-887, Brazil.
Karl Jan ClinckspoorDepartment of Physical Chemistry, Instituto de Química, Universidade Estadual de Campinas, 336, Josué de Castro, Campinas, São Paulo, 13083-970, Brazil.ORCID https://orcid.org/0000-0002-0916-2773
Renan Marrichi MauchCenter for Investigation in Pediatrics, Department of Pediatrics, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 126, Tessália Vieira de Camargo, Campinas, São Paulo, 13083-887, Brazil.
Francisco Benedito Teixeira PessineDepartment of Physical Chemistry, Instituto de Química, Universidade Estadual de Campinas, 336, Josué de Castro, Campinas, São Paulo, 13083-970, Brazil.
Carlos Emilio LevyDepartment of Clinical Pathology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 126, Tessália Vieira de Camargo, Campinas, São Paulo, 13083-887, Brazil.
Andressa Oliveira PeixotoCenter for Investigation in Pediatrics, Department of Pediatrics, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 126, Tessália Vieira de Camargo, Campinas, São Paulo, 13083-887, Brazil.
Maria Ângela Gonçalves Oliveira RibeiroCenter for Investigation in Pediatrics, Department of Pediatrics, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 126, Tessália Vieira de Camargo, Campinas, São Paulo, 13083-887, Brazil.
Antônio Fernando RibeiroCenter for Investigation in Pediatrics, Department of Pediatrics, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 126, Tessália Vieira de Camargo, Campinas, São Paulo, 13083-887, Brazil.
Douglas ConradDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego School of Medicine, 9500 Gilman Dr., La Jolla, CA, 92093-0830, USA.
Paul Marquis QuintonDepartment of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Dr, La Jolla, CA, 92093-0830, USA.
Fernando Augusto Lima MarsonCenter for Investigation in Pediatrics, Department of Pediatrics, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 126, Tessália Vieira de Camargo, Campinas, São Paulo, 13083-887, Brazil. fernandolimamarson@hotmail.com.ORCID http://orcid.org/0000-0003-4955-4234
José Dirceu RibeiroCenter for Investigation in Pediatrics, Department of Pediatrics, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 126, Tessália Vieira de Camargo, Campinas, São Paulo, 13083-887, Brazil. jdirceuribeiro@gmail.com.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/12939-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/18845-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/12183-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/12858-5
6 · The paper itself

Abstract

backgroundAmong the many consequences of loss of CFTR protein function, a significant reduction of the secretion of bicarbonate (HCO

objectiveTo evaluate the safety, tolerability, and effects of inhaled aerosols of NaHCO

methodsAn experimental, prospective, open-label, pilot, clinical study was conducted with 12 CF volunteer participants over 18 years of age with bronchiectasis and pulmonary functions classified as mildly to severely depressed. Sputum rheology, pH, and microbiology were examined as well as spirometry, exercise performance, quality-of-life assessments, dyspnea, blood count, and venous blood gas levels.

resultsSputum pH increased immediately after inhalation of NaHCO

conclusionNebulized NaHCO

Indexed as

Administration, InhalationAdolescentAdultCystic FibrosisElasticityFemaleHumansMalePilot ProjectsProspective StudiesQuality of LifeSodium BicarbonateSputumViscositySodium Bicarbonate

Identifiers

PMID31721070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.