Evidence map›Paper›PMID 31721052›Full record

ArticleNeurotoxicity research2020

Common Variant in TREM1 Influencing Brain Amyloid Deposition in Mild Cognitive Impairment and Alzheimer's Disease.

Yue-Song Liu, Wen-Jing Yan, Chen-Chen Tan, Jie-Qiong Li, Wei Xu, Xi-Peng Cao, Lan Tan, Jin-Tai Yu, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
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In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Proteome-wide Mendelian randomization identifies causal plasma proteins in frontotemporal dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yue-Song Liu *Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, No. 5 Donghai Middle Road, Qingdao, China.
Wen-Jing Yan *Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Chen-Chen TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong Sheng, China.
Jie-Qiong LiDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong Sheng, China.
Wei XuDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong Sheng, China.
Xi-Peng CaoClinical Research Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong Sheng, China.
Lan TanDepartment of Neurology, Qingdao Municipal Hospital, Dalian Medical University, No. 5 Donghai Middle Road, Qingdao, China. dr.tanlan@163.com.
Jin-Tai YuDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, No. 12 Wulumuqi Road, Shanghai, China. yu-jintai@163.com.
Alzheimer’s Disease Neuroimaging Initiative

Funding

National Key R&D Program of China 2018YFC1314700National Natural Science Foundation of China 81771148National Natural Science Foundation of China 91849126Shanghai Municipal Science and Technology Major Project 2018SHZDZX01
6 · The paper itself

Abstract

Triggering receptor expressed on myeloid cells-1 (TREM1) has been reported to associate with Alzheimer's disease (AD) pathology. Recently, TREM1 variant rs2234246

Indexed as

AgedAlzheimer DiseaseAmyloid beta-PeptidesCognitive DysfunctionCross-Sectional StudiesFemaleGenotypeHumansMalePositron-Emission TomographyTriggering Receptor Expressed on Myeloid Cells-1Amyloid beta-PeptidesTREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1Alzheimer’s diseaseAβ depositionPET-AβTREM1

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.