ArticleDocumenta ophthalmologica. Advances in ophthalmology2020
Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- The Mydriasis-Free Handheld ERG Device and Its Utility in Clinical Practice: A Review.Biomedicines · 2026Review
- The reproducibility of handheld ERGs recorded with skin electrode and natural pupils.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Minimizing Pupil Size Dependence in Flicker ERG Using Stiles-Crawford Compensation.Translational vision science & technology · 2025Article
- Circulating Cell-Free DNA as an Epigenetic Biomarker for Early Diabetic Retinopathy: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Measuring differences in the ERG in myopia using the RETeval device with skin electrodes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Effect of Anti-VEGF drugs on diabetic Retinopathy-Microaneurysms: A correlation study.Pakistan journal of medical sciences · 2024Article
- Association between choroidopathy and photoreceptors during the early stage of diabetic retinopathy: a cross-sectional study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Electrophysiological findings in long-term type 1 diabetes patients without diabetic retinopathy using different ERG recording systems.Scientific reports · 2024Article
- Retinal Functional Impairment in Diabetic Retinopathy.Biomedicines · 2023Article
- Visual Evoked Potentials for the Detection of Diabetic Retinal Neuropathy.International journal of molecular sciences · 2023Review
- Preventable risk factors for type 2 diabetes can be detected using noninvasive spontaneous electroretinogram signals.PloS one · 2023Article
- Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening.PloS one · 2023Article
- Electrophysiology as a prognostic indicator of visual recovery in diabetic patients undergoing cataract surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Neuroretinal dysfunction revealed by a flicker electroretinogram correlated with peripheral nerve dysfunction and parameters of atherosclerosis in patients with diabetes.Journal of diabetes investigation · 2021Article
- Effects of recording sequence on flicker electroretinographics recorded with natural pupils corrected for pupil area.Acta ophthalmologica · 2021Article
- A Diagnostic Model for Screening Diabetic Retinopathy Using the Hand-Held Electroretinogram Device RETeval.Frontiers in endocrinology · 2021Observational
- Enhancing Risk Assessment in Patients with Diabetic Retinopathy by Combining Measures of Retinal Function and Structure.Translational vision science & technology · 2020Article
- Predicting Progression to Vision-Threatening Complications in Diabetic Retinopathy.Ophthalmology scienceArticle
- Clinical electroretinography in diabetic retinopathy: a review.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo investigate the accuracy of the RETeval full-field flicker ERG in the screening of diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) and to determine a suitable range of DR diagnostic reference for patients with type 2 diabetes mellitus (T2DM).
methodsThis was a cross-sectional study involving 172 subjects with T2DM, including 71 subjects without clinically detectable DR (NDR), 25 subjects with mild non-proliferative diabetic retinopathy (NPDR), 24 subjects with moderate NPDR, 27 subjects with severe NPDR and 25 subjects with proliferative diabetic retinopathy (PDR). All the subjects underwent a full-field flicker ERG using the RETeval device (DR assessment protocol), which is a mydriasis-free, full-field electroretinogram (ERG) recording system. The performance of the DR assessment protocol in detecting the DR (including mild NPDR, moderate NPDR, severe NPDR and PDR) and VTDR was analyzed with the receiver operating characteristic (ROC) curve.
resultsFor the detection of DR (mild NPDR, moderate NPDR, severe NPDR, PDR), the area under the ROC curve was 0.867 (p < 0.001, 95% CI 0.814-0.920), and the best cutoff value for DR was determined to be 20.75, with a sensitivity of 80.2% and specificity of 81.7%. Meanwhile, for the detection of VTDR, the area under the ROC curve was 0.965 (p < 0.001, 95% CI 0.941-0.989), and the best cutoff value was set to 23.05, with a sensitivity of 94.6% and a specificity of 88.8%.
conclusionThe DR assessment protocol in RETeval device was effective in screening for DR (mild NPDR, moderate NPDR, severe NPDR, PDR) and VTDR in patients with diabetes. It could be helpful in referring and managing patients with T2DM in primary healthcare setting. However, caution should be taken that optimal cutoff value of DR assessment protocol may vary in different ethnic populations.
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