Evidence map›Paper›PMID 31720956›Full record

SynthesisAIDS and behavior2020

Burden of Depression in Outpatient HIV-Infected adults in Sub-Saharan Africa; Systematic Review and Meta-analysis.

S M Lofgren, D J Bond, N Nakasujja, D R Boulware

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in AIDS and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

S M LofgrenDivision of Infectious Diseases and International Medicine, Department of Minnesota, University of Minnesota, 420 Delaware Street, SE, MMC 250, Minneapolis, MN, 55455, USA. Lofg0020@umn.edu.ORCID http://orcid.org/0000-0001-6717-2614
D J BondDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
N NakasujjaDepartment of Psychiatry, Makerere University, Kampala, Uganda.
D R BoulwareDivision of Infectious Diseases and International Medicine, Department of Minnesota, University of Minnesota, 420 Delaware Street, SE, MMC 250, Minneapolis, MN, 55455, USA.

Funding

Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related MeningitisR01NS086312 · NINDS · UNIVERSITY OF MINNESOTA · PI David R Boulware, David Bisagaya Meya · 2013 to 2026
$8.3M
Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
Northern/Pacific Universities Global Health Research Training ConsortiumR25TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI KOLARS, JOSEPH C., NERURKAR, VIVEK RAMCHANDRA · 2012 to 2016
$5.9M
Neuroinflammation and Modulating Factors in Depression and HIVK23MH121220 · NIMH · UNIVERSITY OF MINNESOTA · PI LOFGREN, SARAH · 2019 to 2022
$795k
FIC NIH HHS L30 TW011500FIC NIH HHS R25 TW009345FIC NIH HHS R25TW009345National Institute of Allergy and Infectious Diseases T32AI055433NIAID NIH HHS T32 AI055433NIMH NIH HHS K23 MH121220NINDS NIH HHS R01 NS086312NINDS NIH HHS R01NS086312
6 · The paper itself

Abstract

Despite the substantial burden of HIV in Africa, and the knowledge that depression causes worse HIV outcomes, the burden of depression in people living with HIV in Africa is unknown. We searched Pubmed and four other databases using key terms: depression, Africa, HIV, and prevalence from 2008 to 2018. We summarized depression prevalence by country. We estimated the burden of depression using our prevalence data and 2018 UNAIDS HIV estimates. Our search yielded 70 articles across 16 African countries. The overall prevalence of major depression in those HIV-infected using a diagnostic interview was 15.3% (95% CI 12.5-17.1%). We estimate that 3.63 million (99.7% CI 3.15-4.19 million) individuals with HIV in Sub-Saharan Africa have major depression and provide country-level estimates. We estimate that 1.57 million (99.7% CI 1.37-1.82 million) DALYs are lost among people with depression and HIV in Sub-Saharan Africa. There is a significant burden of depression in Africans with HIV. Further work to screen for and treat depression in Sub-Saharan Africa is needed to improve HIV outcomes and achieve the 90-90-90 UNAIDS goals.

Indexed as

Cost of IllnessQuality of LifeAdultAfrica South of the SaharaAnti-HIV AgentsDepressionDepressive DisorderHIV InfectionsHumansOutpatientsPrevalenceSickness Impact ProfileAnti-HIV AgentsBurden of diseaseDepressionHIVPrevalenceSub-Saharan Africa

Identifiers

PMID31720956
PMCPMC7478178

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.