Evidence map›Paper›PMID 31720917›Full record

ArticleBreast cancer research and treatment2020

Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis.

Satu Tiainen, Amro Masarwah, Sanna Oikari, Kirsi Rilla, Kirsi Hämäläinen, Mazen Sudah, Anna Sutela, Ritva Vanninen, Juho Ikonen, Raija Tammi and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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  13. Advances in Intraoperative Flow Cytometry.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Satu TiainenCancer Center, Kuopio University Hospital, P.O. Box 100, 70029, Kuopio, Finland. satu.tiainen@kuh.fi.ORCID http://orcid.org/0000-0002-5673-8851
Amro MasarwahImaging Center, Clinical Radiology, Kuopio University Hospital, P.O. Box 100, 70029, Kuopio, Finland.
Sanna OikariInstitute of Biomedicine, University of Eastern Finland, P.O.Box 1627, 70211, Kuopio, Finland.
Kirsi RillaInstitute of Biomedicine, University of Eastern Finland, P.O.Box 1627, 70211, Kuopio, Finland.
Kirsi HämäläinenImaging Center, Clinical Pathology, Kuopio University Hospital, P.O. Box 100, 70029, Kuopio, Finland.
Mazen SudahImaging Center, Clinical Radiology, Kuopio University Hospital, P.O. Box 100, 70029, Kuopio, Finland.
Anna SutelaImaging Center, Clinical Radiology, Kuopio University Hospital, P.O. Box 100, 70029, Kuopio, Finland.
Ritva VanninenImaging Center, Clinical Radiology, Kuopio University Hospital, P.O. Box 100, 70029, Kuopio, Finland.
Juho IkonenCancer Center, Kuopio University Hospital, P.O. Box 100, 70029, Kuopio, Finland.
Raija TammiInstitute of Biomedicine, University of Eastern Finland, P.O.Box 1627, 70211, Kuopio, Finland.
Markku TammiInstitute of Biomedicine, University of Eastern Finland, P.O.Box 1627, 70211, Kuopio, Finland.
Päivi AuvinenCancer Center, Kuopio University Hospital, P.O. Box 100, 70029, Kuopio, Finland.
University of Eastern Finland · FIKuopio University Hospital · FI

Funding

Special Government Funding of Kuopio University Hospital 5654132
6 · The paper itself

Abstract

purposeTumor microenvironment, including inflammatory cells, adipocytes and extracellular matrix constituents such as hyaluronan (HA), impacts on cancer progression. Systemic metabolism also influences tumor growth e.g. obesity and type 2 diabetes (T2D) are risk factors for breast cancer. Here, in 262 breast cancer cases, we explored the combined impacts on survival of M2-like tumor associated macrophages (TAMs), the abundance of breast fat visualized as low density in mammograms, and tumor HA, and their associations with T2D.

methodsMammographic densities were assessed visually from the diagnostic images and dichotomized into very low density (VLD, density ≤ 10%, "fatty breast") and mixed density (MID, density > 10%). The amounts of TAMs (CD163+ and CD68+) and tumor HA were determined by immunohistochemistry. The data of T2D was collected from the patient records. Statistical differences between the parameters were calculated with Chi square or Mann-Whitney test and survival analyses with Cox's model.

resultsA combination of fatty breasts (VLD), abundance of M2-like TAMs (CD163+) and tumor HA associated with poor survival, as survival was 88-89% in the absence of these factors but only 40-47% when all three factors were present (p < 0.001). Also, an association between T2D and fatty breasts was found (p < 0.01). Furthermore, tumors in fatty breasts contained more frequently high levels of M2-like TAMs than tumors in MID breasts (p = 0.01).

conclusionsOur results demonstrate a dramatic effect of the tumor microenvironment on breast cancer progression. We hypothesize that T2D as well as obesity increase the fat content of the breasts, subsequently enhancing local pro-tumoral inflammation.

Indexed as

AdipocytesAdipose TissueAdultAgedAged, 80 and overBreastBreast DensityBreast NeoplasmsDiabetes Mellitus, Type 2Disease-Free SurvivalFemaleHumansHyaluronic AcidMacrophagesMiddle AgedObesityHyaluronic AcidBreast cancerBreast densityDiabetesHyaluronanMacrophageObesity

Identifiers

PMID31720917
PMCPMC6997252
OpenAlexW2988639805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.