Evidence map›Paper›PMID 31720862›Full record

ReviewCurrent neurology and neuroscience reports2019

Exercise as Medicine in Multiple Sclerosis-Time for a Paradigm Shift: Preventive, Symptomatic, and Disease-Modifying Aspects and Perspectives.

Ulrik Dalgas, Martin Langeskov-Christensen, Egon Stenager, Morten Riemenschneider, Lars G Hvid

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 8 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 8 syntheses or guidelines pooled it, 268 citations in OpenAlex.

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  15. Article
  16. Associations between lifestyle factors and 2.5-year clinical outcomes differ by time since multiple sclerosis diagnosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ulrik DalgasDepartment of Public Health, Section for Sport Science, Aarhus University, Aarhus, Denmark. dalgas@ph.au.dk.
Martin Langeskov-ChristensenDepartment of Public Health, Section for Sport Science, Aarhus University, Aarhus, Denmark.
Egon StenagerDepartment of Neurology, Hospital of Southern Jutland, Sønderborg, Denmark.
Morten RiemenschneiderDepartment of Public Health, Section for Sport Science, Aarhus University, Aarhus, Denmark.
Lars G HvidDepartment of Public Health, Section for Sport Science, Aarhus University, Aarhus, Denmark.
Aarhus University · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewFor many years, exercise was controversial in multiple sclerosis (MS) and thought to exacerbate symptoms and fatigue. However, having been found to be safe and effective, exercise has become a cornerstone of MS rehabilitation and may have even more fundamental benefits in MS, with the potential to change clinical practice again. The aim of this review is to summarize the existing knowledge of the effects of exercise as primary, secondary, and tertiary prevention in MS. RECENT

findingsInitial studies established exercise as an effective symptomatic treatment (i.e., tertiary prevention), but recent studies have evaluated the disease-modifying effects (i.e., secondary prevention) of exercise as well as the impact on the risk of developing MS (i.e., primary prevention). Based on recent evidence, a new paradigm shift is proposed, in which exercise at an early stage should be individually prescribed and tailored as "medicine" to persons with MS, alongside conventional medical treatment.

Indexed as

Exercise TherapyHumansMultiple SclerosisClinical exercise physiologyExercise therapyKinesiologyNeurological disorderPhysical activityTraining

Identifiers

PMID31720862
OpenAlexW2983125340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.