ArticleJournal of neurology2020
Wake-up stroke: thrombolysis reduces ischemic lesion volume and neurological deficit.
Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Beyond conventional imaging: A systematic review and meta-analysis assessing the impact of computed tomography perfusion on ischemic stroke outcomes in the late window.International journal of stroke : official journal of the International Stroke Society · 2025Pooled it
- Efficacy and safety of rt-PA intravenous thrombolysis in patients with wake-up stroke: A meta-analysis.Medicine · 2022Pooled it
- Atrial fibrillation detected after ischemic stroke (AFDAS) diagnosed by short-term monitoring: the importance of frontal hypoperfusion.Journal of thrombosis and thrombolysis · 2026Article
- Crossed cerebellar diaschisis on CT perfusion in large vessel occlusion stroke: early predictors and clinical relevance in the hyperacute phase.Journal of neurology · 2026Article
- Copeptin as a promising biomarker of cerebrovascular events: A minireview.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026Review
- Role of beta-blocker therapy on the sympathetic effects in stroke heart syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Effectiveness of CT perfusion in posterior circulation stroke: evaluation of perfusion abnormalities and associated clinical signs.Journal of neurology · 2025Article
- Sex differences in Wake-Up Stroke patients characteristics and outcomes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Stroke heart injury: the effect of cerebral reperfusion treatment. A 3-year retrospective study.Journal of neurology · 2024Article
- Improving acute stroke assessment in non-enhanced computed tomography: automated tool for early ischemic lesion volume detection.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Multicentre registration of wake-up stroke in China (MCRWUSC): a protocol for a prospective, multicentre, registry-based cohort study.BMJ open · 2022Article
- Surrogate biomarkers of outcome for wake-up ischemic stroke.BMC neurology · 2022Article
- Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study.Journal of neurology · 2022Observational
- Wake-up stroke: imaging-based diagnosis and recanalization therapy.Journal of neurology · 2021Review
- Multimodal CT pc-ASPECTS in infratentorial stroke: diagnostic and prognostic value.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Early EEG Alterations Correlate with CTP Hypoperfused Volumes and Neurological Deficit: A Wireless EEG Study in Hyper-Acute Ischemic Stroke.Annals of biomedical engineering · 2021Article
- CT perfusion in hyper-acute ischemic stroke: the acid test for COVID-19 fear.Neuroradiology · 2021Observational
- Multimodal CT Imaging Characteristics in Predicting Prognosis of Wake-Up Stroke.Frontiers in neurology · 2021Article
- Hyper-acute EEG alterations predict functional and morphological outcomes in thrombolysis-treated ischemic stroke: a wireless EEG study.Medical & biological engineering & computing · 2021Article
- Has COVID-19 played an unexpected "stroke" on the chain of survival?Journal of the neurological sciences · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundsWake-Up Stroke (WUS) patients are generally excluded from thrombolytic therapy (rTPA) due to the unknown time of stroke onset. This study aimed to investigate the effects of rTPA in WUS patients during every day clinical scenarios, by measuring ischemic lesion volume and functional outcomes compared to non-treated WUS patients.
methodsWe retrospectively analyzed clinical and imaging data of 149 (75 rTPA; 74 non-rTPA) patients with acute ischemic WUS. Ischemic volume was calculated on follow-up CT and functional outcomes were the NIHSS and mRS comparing rTPA and non-rTPA WUS. Patients were selected using ASPECTS > 6 on CT and/or ischemic penumbra > 50% of hypoperfused tissue on CTP.
resultsA reduced volume was measured on the follow-up CT for rTPA (1 mL, 0-8) compared to the non-rTPA patients (10 mL, 0-40; p = 0.000). NIHSS at 7 days from admission was significantly lower in the rTPA (1, 0-4) compared to non-rTPA group (3, 1-9; p = 0.015), as was the percentage of improvement (ΔNIHSS) (70% vs 50%; p = 0.002). A higher prevalence of mRS 0-2 was observed in the rTPA compared to the non-rTPA (54% vs 39%; p = 0.060). Multivariate analysis showed that NIHSS at baseline and rTPA treatment are significant predictors of good outcome both in terms of NIHSS at 7 days and ischemic lesion volume on follow-up CT (p < 0.05).
conclusionsrTPA in WUS patients selected with CT and/or CTP resulted in reduced ischemic infarct volume on follow-up CT and better functional outcome without increment of intracranial hemorrhages and in-hospital mortality.
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