Trial reportJournal of neurology2020
Post-stroke cognitive impairment as an independent predictor of ischemic stroke recurrence: PICASSO sub-study.
Trial report in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 8 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- The performance of machine learning for predicting the recurrent stroke: a systematic review and meta-analysis on 24,350 patients.Acta neurologica Belgica · 2025Pooled it
- Neuroimaging evidence of acupuncture in cognitive impairment following ischemic stroke: a systematic review.Frontiers in neuroscience · 2025Pooled it
- The role of serum albumin and albumin-related nutritional indices in predicting post-stroke cognitive impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Poststroke Cognitive Impairment and the Risk of Recurrent Stroke and Mortality: Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2024Pooled it
- Comparative efficacy of non-invasive brain stimulation for post-stroke cognitive impairment: a network meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Pooled it
- Network meta-analysis of non-pharmacological interventions for cognitive impairment after an ischemic stroke.Frontiers in neurology · 2024Pooled it
- The efficacy and safety of post-stroke cognitive impairment therapies: an umbrella review.Frontiers in pharmacology · 2023Pooled it
- Effect of acupuncture treatment on post-stroke cognitive impairment: A randomized controlled trial.Medicine · 2020Trial
- Adult-onset opsoclonus-myoclonus-ataxia syndrome accompanying an infection with tick-borne encephalitis virus: A case report.Acta neurologica Belgica · 2025Article
- Feasibility of telephone and computerized cognitive testing as a secondary outcome in an acute stroke clinical trial: A mixed methods sub-study of the AcT Trial.European stroke journal · 2025Article
- StrokeCog-15 Is an Efficient Neuropsychological Battery to Screen for Cognitive Impairment in Chronic Stroke.Stroke · 2025Observational
- Cognitive Assessments in Randomized Controlled Trials of Acute or Secondary Prevention Stroke Treatments 2011 to 2024: A Scoping Review.Journal of the American Heart Association · 2025Article
- Anti-GFAP associated opsoclonus-myoclonus-ataxia syndrome in a patient with multiple autoimmune comorbidities-a case report.Journal of neurology · 2025Article
- Microbiota-gut-brain-axis: a new target of acupuncture therapy for post-stroke cognitive impairment.Frontiers in microbiology · 2025Review
- Inter-rater and intra-rater reliability of the Chinese version of the short orientation-memory-concentration test in people with stroke.Frontiers in rehabilitation sciences · 2025Article
- Knowledge domain and emerging trends in post-stroke cognitive impairment: a bibliometric analysis.Frontiers in aging neuroscience · 2025Article
- A New Perspective in the Treatment of Ischemic Stroke: Ferroptosis.Neurochemical research · 2024Review
- Potential Protein Signatures for Recurrence Prediction of Ischemic Stroke.Journal of the American Heart Association · 2024Article
- Enriched rehabilitation on brain functional connectivity in patients with post-stroke cognitive impairment.Frontiers in neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
introductionTo devise appropriate preventive strategies after stroke, knowledge of the association between post-stroke cognitive impairment (PSCI) and prognosis of stroke patients is important. We investigated the association between PSCI and the vascular outcomes in patients with ischemic stroke with best medical care considering their risk factors and adherence to medications.
methodsOf the 1534 ischemic stroke patients who randomly assigned to aspirin or cilostazol treatment with best medical therapy by the PICASSO (PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage) trial, 1240 with baseline mini-mental state examination (MMSE) scores were analysed retrospectively. The patients were classified into three groups based on MMSE scores. Recurrence of ischemic stroke, stroke of any type and composite of major vascular events were compared among them.
resultsOf the 1240 patients, 376 had MMSE scores of 28-30 (highest tertile), 419 had scores of 24-27 (middle tertile) and 445 had scores of 0-23 (lowest tertile). The average time from stroke onset to MMSE examination was 31.8 days. By trend analysis, lower tertile of MMSE score was significantly associated with recurrent ischemic stroke (p = 0.0017), stroke of any type (p = 0.0053) and composite vascular outcome (p = 0.0122). After adjustment for covariates, PSCI was independently associated with risk of recurrent ischemic stroke (HR 2.40, 95% confidence interval 1.12-5.14).
conclusionsCognitive impairment was associated with recurrence of ischemic stroke in high risk patients during adequate medical therapy including antiplatelet therapy. However, the other vascular events were not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.