ArticleSurgery today2020
Prognostic value of the preoperative prognostic nutritional index in oldest-old patients with colorectal cancer.
Article in Surgery today, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Prognostic value of the prognostic nutritional index in colorectal cancer: a systematic review and meta-analysis.BMC gastroenterology · 2026Pooled it
- Nutritional conditions and PFS and OS in cancer immunotherapy: the MOUSEION-010 meta-analysis.Immunotherapy · 2025Pooled it
- The CALLY index as a predictive biomarker for the prognosis and treatment outcomes of colorectal cancer.Surgery today · 2026Article
- Association of Preoperative Prognostic Nutritional Index on Long-Term Outcomes and Postoperative Complications of Stage I-III Colorectal Cancer.Cancer medicine · 2026Article
- Longitudinal trajectories of nutritional markers in patients with de novo Stage IV gastric cancer: a descriptive analysis using one-year survival as a reference.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Diagnostic utility and discriminative ability of cholesterol-modified prognostic nutritional index and inflammatory indicators in colorectal cancer: a retrospective case-control study.Scientific reports · 2026Article
- Robotic versus laparoscopic surgery in older colorectal cancer patients: a comparison of clinical outcomes and inflammatory markers.BMC geriatrics · 2026Article
- Clinical value of the novel inflammatory-nutritional marker PALR in predicting early postoperative recurrence of colorectal cancer.Discover oncology · 2025Article
- Prognostic value of routine blood biomarkers in 3-year survival of resectable colorectal cancer patients: a prognostic nomogram for clinical practice.International journal of colorectal disease · 2025Observational
- The Preoperative C-reactive Protein/Albumin Ratio of Immune-inflammation Index Is an Independent Prognostic Factor of Advanced Colorectal Cancer in Older Patients (≥ 65 years).Journal of the anus, rectum and colon · 2025Article
- Impact of perioperative prognostic nutritional index changes on the survival of patients with stage II/III colorectal cancer.Annals of gastroenterological surgery · 2024Article
- Lymph node ratio and hematological parameters predict relapse-free survival in patients with high grade rectal neuroendocrine neoplasms after radical resection: a multicenter prognostic study.World journal of surgical oncology · 2023Article
- Article
- Elective colorectal cancer surgery in nonagenarians and postoperative outcomes.Updates in surgery · 2023Article
- Prognostic nomograms integrating preoperative serum lipid derivative and systemic inflammatory marker of patients with non-metastatic colorectal cancer undergoing curative resection.Frontiers in oncology · 2023Article
- Efficacy of Neutrophil-to-Lymphocyte Ratio for Cancer-Specific Survival in Elderly Patients with Localized Colon Cancer: A Single Center Propensity Score-Matched Analysis.Clinical and experimental gastroenterology · 2023Article
- A Novel Prognostic Index for Metastatic Colon Cancer: The Prognostic Immune Nutritional Index.Cureus · 2023Article
- The prognostic effect of sixteen malnutrition/inflammation-based indicators on the overall survival of chemotherapy patients.Frontiers in immunology · 2023Article
- The preoperative geriatric nutritional risk index (GNRI) is an independent prognostic factor in elderly patients underwent curative resection for colorectal cancer.Scientific reports · 2022Article
- C-reactive protein/albumin ratio predicts survival after curative surgery in elderly patients with colorectal cancer.Updates in surgery · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic nutritional index (PNI), which is calculated using serum albumin and the peripheral lymphocyte count, is a simple and useful score for predicting the prognosis in patients with various cancers. The correlation between the preoperative PNI and long-term outcomes is unclear in oldest-old patients with colorectal cancer.
methodsA total of 84 consecutive patients ≥ 85 years old who underwent resection for primary colon adenocarcinoma at our institution between April 2008 and March 2017 were retrospectively reviewed. The cut-off value of the PNI for predicting the relapse-free survival (RFS) was 42.4 on a receiver operating characteristic curve analysis. The clinical characteristics and markers of systemic inflammation were then compared between patients with a low PNI (PNI < 42.4, n = 33) and a high PNI (PNI ≥ 42.4, n = 51).
resultsA low PNI was associated with systemic inflammation marker levels, including a low neutrophil-to-lymphocyte ratio (p = 0.048), a low platelet-to-lymphocyte ratio (p = 0.006), and a high lymphocyte-to-monocyte ratio (p < 0.001). The median follow-up period of this cohort was 34 months (1-151 months). The 5-year RFS, overall survival (OS), and cancer-specific survival were significantly worse in the low-PNI group than in the high-PNI group (p = 0.032, p = 0.004, p = 0.049, respectively). In the multivariate analysis, a low PNI was an independent predictor for both the RFS (HR 3.188, p = 0.041) and OS (HR 3.953, p = 0.027).
conclusionsA low-preoperative PNI was significantly associated with a poor prognosis in oldest-old colorectal cancer patients. Perioperative nutritional support may be important for prolonging the survival.
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