Evidence map›Paper›PMID 31720762›Full record

ArticleExperimental brain research2019

NRG1-ErbB4 signaling promotes functional recovery in a murine model of traumatic brain injury via regulation of GABA release.

Weike Deng, Fei Luo, Bao-Ming Li, Lin Mei

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 40 citations in OpenAlex.

  1. Drug Repurposing for Treating NCOR-Related Intellectual Disability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  2. Review
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  10. ErbB4 in parvalbumin-positive interneurons mediates proactive interference in olfactory associative reversal learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  11. Article
  12. Review
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Weike DengSchool of Life Science, Nanchang University, 999 Xuefu Road, Nanchang, 330031, People's Republic of China.
Fei LuoInstitute of Life Science, Nanchang University, 999 Xuefu Road, Nanchang, 330031, People's Republic of China. luofei@ncu.edu.cn.
Bao-Ming LiSchool of Life Science, Nanchang University, 999 Xuefu Road, Nanchang, 330031, People's Republic of China.
Lin MeiDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Nanchang University · CNCharlie Norwood VA Medical Center · US

Funding

National Natural Science Foundation of China 31771182National Natural Science Foundation of China 81471116National Natural Science Foundation of China 81560196Natural Science Foundation of Jiangxi Province 20171ACB20002
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a serious health problem in the world. However, little is known about the pathogenesis and molecular mechanisms of TBI. Here, we show that TBI activates neuregulin 1 (NRG1)-ErbB4 signaling, with an increased expression of NRG1 and ErbB4 in the traumatic region. Specifically knocking out ErbB4 in parvalbumin-positive (PV

Indexed as

Brain Injuries, TraumaticParietal LobeAnimalsBehavior, AnimalCell DeathCells, CulturedDisease Models, AnimalGABA Antagonistsgamma-Aminobutyric AcidGlutamic AcidMiceMice, Inbred C57BLMice, KnockoutNeuregulin-1NeuronsNeuroprotectionErbb4 protein, mouseGABA Antagonistsgamma-Aminobutyric AcidGlutamic AcidNeuregulin-1Nrg1 protein, mouseReceptor, ErbB-4GABANeuroprotectionNRG1–ErbB4 signalingTraumatic brain injury

Identifiers

PMID31720762
OpenAlexW2984599721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.