ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020
Subclinical thyroid dysfunction, bone mineral density, and osteoporosis in a middle-aged Korean population.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Multiple thyroid disorders and risk of osteoporosis: a two-sample Mendelian randomization study.Journal of bone and mineral metabolism · 2025Pooled it
- Association Between Systemic Immune-Inflammation Index and Thyroid Function: A Cross-Sectional Population-Based Study.International journal of endocrinology · 2026Article
- Bone mineral density assessment by DXA in disease-associated osteoporosis: the limitations.Frontiers in endocrinology · 2026Review
- Association between thyroid function and osteopenia or osteoporosis: a cross-sectional study in China.Scientific reports · 2025Article
- The mediating role of thyroid-related hormones between thyroid dysfunction diseases and osteoporosis: a mediation mendelian randomization study.Scientific reports · 2025Article
- Hair and Serum Trace Element and Mineral Levels Profiles in Women with Premenopausal and Postmenopausal Osteoporosis.Biological trace element research · 2024Article
- Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis.Scientific reports · 2024Article
- Body composition changes in patients with differentiated thyroid cancer after iodine-131 treatment and short-term levothyroxine replacement and suppression therapy.Hormones (Athens, Greece) · 2024Article
- Hypothyroidism correlates with osteoporosis: potential involvement of lipid mediators.Frontiers in medicine · 2024Article
- Effects of short- and long-term TSH suppression on lumbar bone mineral density in both genders using PET/CT.Scientific reports · 2023Article
- Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study.Journal of orthopaedic surgery and research · 2023Article
- Endocrine Regulation on Bone by Thyroid.Frontiers in endocrinology · 2022Review
- Association between Sensitivity to Thyroid Hormone Indices and Bone Mineral Density in US Males.International journal of endocrinology · 2022Article
- Thyrotropin, Hyperthyroidism, and Bone Mass.The Journal of clinical endocrinology and metabolism · 2021Review
- Trabecular bone score in women with differentiated thyroid cancer on long-term TSH-suppressive therapy.Journal of endocrinological investigation · 2021Article
- Thyroid Hormone Diseases and Osteoporosis.Journal of clinical medicine · 2020Review
- The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review.Diagnostics (Basel, Switzerland) · 2020Review
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11 authors at 2 institutions in 1 country.
Funding
Abstract
Thyroid dysfunction is associated with the loss of bone density (osteoporosis). However, the connection between subclinical thyroid dysfunction and osteoporosis remains controversial. This study found no apparent association between subclinical hypothyroidism or subclinical hyperthyroidism and bone mineral density (BMD) in the lumbar spine and femur.
introductionThe present study examined the relationship between subclinical thyroid dysfunction and BMD in healthy middle-aged adults.
methodsA total of 25,510 healthy Koreans with normal free thyroxine levels were enrolled from January 2011 to December 2016, and 91% of subjects visited only once. The average age of the 15,761 women was 45, and the average age of the 9749 men was 48. Levels of thyroid-stimulating hormone (TSH) and BMD were recorded in all subjects. BMD was measured using dual-energy X-ray absorptiometry.
resultsNo apparent association was found between subclinical thyroid dysfunction and BMD in the lumbar spine, femur-neck, and proximal femur sites compared with a euthyroid group. Age, body mass index (BMI), and postmenopausal status affected BMD in women, and only BMI affected BMD in men. Subclinical hypothyroidism was independently associated with a lower risk of osteoporosis (odds ratio 0.657, 95% confidence interval 0.464-0.930) in 4710 postmenopausal women.
conclusionsNo apparent association was found between subclinical hypothyroidism or subclinical hyperthyroidism defined on single TSH measurement and BMD at the lumbar spine and femur in a large cohort of middle-aged men and women. Subclinical hypothyroidism was independently associated with a lower risk of osteoporosis in postmenopausal women.
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