Evidence map›Paper›PMID 31720684›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Temporal and Genotypic Associations of Sporadic Norovirus Gastroenteritis and Reported Norovirus Outbreaks in Middle Tennessee, 2012-2016.

Meghana P Parikh, Simon Vandekar, Christina Moore, Linda Thomas, Nathan Britt, Bhinnata Piya, Laura S Stewart, Einas Batarseh, Lubna Hamdan, Steffany J Cavallo and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Meghana P ParikhVanderbilt University Medical School, Nashville, Tennessee, USA.
Simon VandekarDepartment of Biostatistics, Vanderbilt University, Nashville, Tennessee, USA.
Christina MooreDivision of Laboratory Services, Tennessee Department of Health, Nashville, Tennessee, USA.
Linda ThomasDivision of Laboratory Services, Tennessee Department of Health, Nashville, Tennessee, USA.
Nathan BrittDivision of Laboratory Services, Tennessee Department of Health, Nashville, Tennessee, USA.
Bhinnata PiyaDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Laura S StewartDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Einas BatarsehDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lubna HamdanDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Steffany J CavalloCommunicable and Environmental Diseases and Emergency Preparedness, Tennessee Department of Health, Nashville, Tennessee, USA.
Ashley M SwingCommunicable and Environmental Diseases and Emergency Preparedness, Tennessee Department of Health, Nashville, Tennessee, USA.
Katie N GarmanCommunicable and Environmental Diseases and Emergency Preparedness, Tennessee Department of Health, Nashville, Tennessee, USA.
Lisha Constantine-RennaCommunicable and Environmental Diseases and Emergency Preparedness, Tennessee Department of Health, Nashville, Tennessee, USA.
James ChappellDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Daniel C PayneDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jan VinjéDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Aron J HallDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
John R DunnCommunicable and Environmental Diseases and Emergency Preparedness, Tennessee Department of Health, Nashville, Tennessee, USA.
Natasha HalasaDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Impact of the Initial Influenza Exposure on the Quality, Magnitude, Breadth, Potency and Durability of Influenza ImmunityU01AI144673 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI STAAT, MARY A · 2019 to 2025
$36.4M
Enhanced Surveillance for New Vaccine Preventable DiseasesU01IP001059 · IP · CINCINNATI CHILDRENS HOSP MED CTR · PI STAAT, MARY A · 2016 to 2020
$12.3M
Research on the Epidemiology, Vaccine Effectiveness and Treatment of Influenza and Other Respiratory Viruses in Southeast Asia and the Western PacificU01IP001064 · IP · UNIVERSITY OF HONG KONG · PI COWLING, BENJAMIN JOHN · 2016 to 2020
$10.4M
Enhanced Surveillance for New Vaccine Preventable DiseasesU01IP001063 · IP · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HALASA, NATASHA BASSAM · 2016 to 2020
$6.3M
NCATS NIH HHS UL1 TR000445NCIRD CDC HHS U01 IP001059NCIRD CDC HHS U01 IP001063NCIRD CDC HHS U01 IP001064NIAID NIH HHS U01 AI144673
6 · The paper itself

Abstract

backgroundIn the United States, surveillance of norovirus gastroenteritis is largely restricted to outbreaks, limiting our knowledge of the contribution of sporadic illness to the overall impact on reported outbreaks. Understanding norovirus transmission dynamics is vital for improving preventive measures, including norovirus vaccine development.

methodsWe analyzed seasonal patterns and genotypic distribution between sporadic pediatric norovirus cases and reported norovirus outbreaks in middle Tennessee. Sporadic cases were ascertained via the New Vaccine Surveillance Network in a single county, while reported norovirus outbreaks from 7 middle Tennessee counties were included in the study. We investigated the predictive value of sporadic cases on outbreaks using a 2-state discrete Markov model.

resultsBetween December 2012 and June 2016, there were 755 pediatric sporadic norovirus cases and 45 reported outbreaks. Almost half (42.2%) of outbreaks occurred in long-term care facilities. Most sporadic cases (74.9%) and reported outbreaks (86.8%) occurred between November and April. Peak sporadic norovirus activity was often contemporaneous with outbreak occurrence. Among both sporadic cases and outbreaks, GII genogroup noroviruses were most prevalent (90.1% and 83.3%), with GII.4 being the dominant genotype (39.0% and 52.8%). The predictive model suggested that the 3-day moving average of sporadic cases was positively associated with the probability of an outbreak occurring.

conclusionsDespite the demographic differences between the surveillance populations, the seasonal and genotypic associations between sporadic cases and outbreaks are suggestive of contemporaneous community transmission. Public health agencies may use this knowledge to expand surveillance and identify target populations for interventions, including future vaccines.

Indexed as

Caliciviridae InfectionsGastroenteritisNorovirusChildDisease OutbreaksGenotypeHumansPhylogenyRNA, ViralTennesseeRNA, Viralgastroenteritisnorovirusoutbreaksporadicsurveillance

Identifiers

PMID31720684
PMCPMC7904060

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.