Evidence map›Paper›PMID 31720456›Full record

ArticleHeliyon2019

Melatonin has profound effects on mitochondrial dynamics in myocardial ischaemia/reperfusion.

K Dube, K Dhanabalan, R Salie, M Blignaut, B Huisamen, A Lochner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Evidence for the Benefits of Melatonin in Cardiovascular Disease.Frontiers in cardiovascular medicine · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

K DubeDivision of Medical Physiology, Faculty of Medicine and Health Sciences, University of Stellenbosch, PO Box 241, Tygerberg 7505, South Africa.
K DhanabalanDivision of Medical Physiology, Faculty of Medicine and Health Sciences, University of Stellenbosch, PO Box 241, Tygerberg 7505, South Africa.
R SalieDivision of Medical Physiology, Faculty of Medicine and Health Sciences, University of Stellenbosch, PO Box 241, Tygerberg 7505, South Africa.
M BlignautDivision of Medical Physiology, Faculty of Medicine and Health Sciences, University of Stellenbosch, PO Box 241, Tygerberg 7505, South Africa.
B HuisamenDivision of Medical Physiology, Faculty of Medicine and Health Sciences, University of Stellenbosch, PO Box 241, Tygerberg 7505, South Africa.
A LochnerDivision of Medical Physiology, Faculty of Medicine and Health Sciences, University of Stellenbosch, PO Box 241, Tygerberg 7505, South Africa.
Stellenbosch University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research focus recently shifted to mitochondrial dynamics and the role of fusion and fission in cardioprotection. The aim of this study was to evaluate (i) the function and dynamics of mitochondria isolated from hearts exposed to ischaemia/reperfusion (I/R) (ii) the effects of melatonin, a powerful cardioprotectant, on mitochondrial dynamics in I/R. Isolated perfused rat hearts were stabilized for 30 min, subjected to 20 min global ischaemia, followed by 30 min reperfusion. Tissue was collected, mitochondria isolated for measurement of mitochondrial oxidative function and lysates from mitochondrial and cytosolic fractions prepared for western blotting. Melatonin (0.3 or 50 μM) was administered for 10 min immediately before the onset of ischaemia and for 10 min at the onset of reperfusion. Infarct size was assessed after 35 min regional ischaemia/60

Indexed as

AutophagyCardiologyCardioprotectionDrp-1Laboratory medicineMelatoninMitochondrial fissionMitochondrial oxidative phosphorylationMitophagyMusculoskeletal systemp62PharmacologyPhysiologyULK1

Identifiers

PMID31720456
PMCPMC6838907
OpenAlexW2984385062

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.