Evidence map›Paper›PMID 31720452›Full record

ArticleHeliyon2019

Characterization of phospholipid vesicles containing lauric acid: physicochemical basis for process and product development.

Laura Farkuh, Paulo T Hennies, Cláudia Nunes, Salette Reis, Luisa Barreiros, Marcela A Segundo, Pedro L Oseliero Filho, Cristiano L P Oliveira, Alexandre Cassago, Rodrigo V Portugal and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Laura FarkuhDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Paulo T HenniesLíbera Tecnologia e Inovação Ltda., São Paulo, Brazil.
Cláudia NunesLAQV, REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Salette ReisLAQV, REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Luisa BarreirosLAQV, REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Marcela A SegundoLAQV, REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Pedro L Oseliero FilhoDepartment of Experimental Physics, Institute of Physics, University of São Paulo, São Paulo, Brazil.
Cristiano L P OliveiraDepartment of Experimental Physics, Institute of Physics, University of São Paulo, São Paulo, Brazil.
Alexandre CassagoBrazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil.
Rodrigo V PortugalBrazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil.
Rodrigo A MuramotoDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Gustavo P B CarreteroDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Shirley SchreierDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Hernan ChaimovichDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Iolanda M CuccoviaDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRUniversidade do Porto · PTBrazilian Center for Research in Energy and Materials · BRLíbera Tecnologia e Inovação (Brazil) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lauric acid (LAH) strongly inhibits the growth of acne-causing bacteria. LAH is essentially water-insoluble and the solubility of laurate (LA) salts are medium and temperature dependent. Hence, LAH/LA preparations are difficult to formulate. Here we fully characterized phospholipid vesicles containing up to 50 mol% LAH. Vesicles of dipalmitoylphosphatidylcholine (DPPC) containing LAH, at pHs 7.4 and 5.0, were characterized measuring size, charge, bilayer phase transition temperature (Tm) and permeability of water-soluble probes. Small angle X-ray scattering and

Indexed as

BiotechnologyCryo-TEMDLSDSCIonizable soluteLauric acidLipid VesiclesPharmaceutical ScienceSAXS

Identifiers

PMID31720452
PMCPMC6838897
OpenAlexW2986307968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.