ArticlePractical laboratory medicine2020
Simultaneous analysis of 25 trace elements in micro volume of human serum by inductively coupled plasma mass spectrometry (ICP-MS).
Article in Practical laboratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 37 citations in OpenAlex.
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- Investigation of the Effect of Omega-3 Fatty Acids on Antioxidant System and Serum Aluminum, Zinc, and Iron Levels in Acute Aluminum Toxicity.Biological trace element research · 2025Article
- Review
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- A Bayesian network for estimating hypertension risk due to occupational aluminum exposure.Chronic diseases and translational medicine · 2024Article
- The Role of Reduced Glutathione on the Activity of Adenosine Deaminase, Antioxidative System, and Aluminum and Zinc Levels in Experimental Aluminum Toxicity.Biological trace element research · 2023Article
- Vero cells gain renal tubule markers in low-calcium and magnesium chemically defined media.Scientific reports · 2022Article
- ICP-MS Multi-Elemental Analysis of the Human Meninges Collected from Sudden Death Victims in South-Eastern Poland.Molecules (Basel, Switzerland) · 2022Article
- Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis.Frontiers in immunology · 2022Article
- Association between bone trace elements and osteoporosis in older adults: a cross-sectional study.Therapeutic advances in musculoskeletal disease · 2022Article
- Trace Element Analysis in Whole Blood and Plasma for Reference Levels in a Selected Queensland Population, Australia.International journal of environmental research and public health · 2021Article
- Delineating colorectal cancer distribution, interaction, and risk prediction by environmental risk factors and serum trace elements.Scientific reports · 2020Article
- Development of digital health management systems in longitudinal study: The Malaysian cohort experience.Digital healthArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn recent years, trace elements have gained importance as biomarkers in many chronic diseases. Unfortunately, the requirement for sample volume increases with the extent of investigation either for diagnosis or elucidating the mechanism of the disease. Here, we describe the method development and validation for simultaneous determination of 25 trace elements (lithium [Li], beryllium [Be], magnesium [Mg], aluminium [Al], vanadium [V], chromium [Cr], manganese [Mn], iron [Fe], cobalt [Co], nickel [Ni], copper [Cu], zinc [Zn], gallium [Ga], arsenic [As], selenium [Se], rubidium [Rb], strontium [Sr], silver [Ag], cadmium [Cd], caesium [Cs], barium [Ba], mercury [Hg], thallium [Tl], lead [Pb], uranium [U]) using only 20 μL of human serum.
methodsSerum samples were digested with nitric acid and hydrochloric acid (ratio 1:1, v/v) and analysed by inductively coupled plasma-mass spectrometry (ICP-MS). Seronorm®, a human-derived serum control material was used as quality control samples.
resultsThe coefficient of variations for both intra- and inter-day precisions were consistently <15% for all elements. The validated method was later tested on 30 human serum samples to evaluate its applicability.
conclusionWe have successfully developed and validated a precise and accurate analytical method for determining 25 trace elements requiring very low volume of human serum.
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