Evidence map›Paper›PMID 31720243›Full record

ArticleAsia Pacific allergy2019

Respiratory syncytial virus increases eosinophil extracellular traps in a murine model of asthma.

Josiane Silva Silveira, Géssica Luana Antunes, Rodrigo Benedetti Gassen, Ricardo Vaz Breda, Renato Tetelbom Stein, Paulo Márcio Pitrez, Aline Andrea da Cunha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asia Pacific allergy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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  12. The "Self-Sacrifice" of ImmuneCells in Sepsis.Frontiers in immunology · 2022
    Review
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  15. Eosinophil responses during COVID-19 infections and coronavirus vaccination.The Journal of allergy and clinical immunology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Josiane Silva SilveiraDepartment of Biochemistry, Laboratory of Neuroprotection and Neurometabolic Disease, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Géssica Luana AntunesLaboratory of Pediatric Respirology - Infant Center, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.
Rodrigo Benedetti GassenLaboratory of Cellular and Molecular Immunology, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.
Ricardo Vaz BredaLaboratory of Neuroscience - Brain Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.
Renato Tetelbom SteinLaboratory of Pediatric Respirology - Infant Center, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.
Paulo Márcio PitrezLaboratory of Pediatric Respirology - Infant Center, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.
Aline Andrea da CunhaLaboratory of Pediatric Respirology - Infant Center, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0002-1059-360X
Hospital Moinhos de Vento · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory viral infections are the leading cause of asthma exacerbations. Eosinophil activation results in the formation of eosinophil extracellular traps (EETs), which release web-like structures of DNA and proteins that bind, disarm and extracellularly kill pathogens.

objectiveWe investigated whether the respiratory syncytial virus (RSV)

methodsBALB/cJ mice (6-8 weeks old) were sensitized with 2 subcutaneous injections of ovalbumin (20 μg) on days 0 and 7, followed by three intranasal challenges with ovalbumin (100 μg) on days 14, 15, and 16 of the protocol. The control group received Dulbecco's phosphate-buffered saline. Bronchoalveolar lavage fluid eosinophils of ovalbumin group or control group were stimulated with RSV (10

resultsWe verified an increase in extracellular DNA concentration in bronchoalveolar lavage fluid eosinophils from ovalbumin group stimulated with RSV (10

conclusionIn this study, we demonstrated for the first time that RSV

Indexed as

AsthmaEosinophil peroxidaseExtracellular trapsInflammationRespiratory syncytial viruses

Identifiers

PMID31720243
PMCPMC6826116
OpenAlexW2980502541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.