Evidence map›Paper›PMID 31720225›Full record

ArticleIDCases2019

A healthy patient with positive mantoux test but negative quantiferon Gold assay and no evidence of risk factors - to treat or not to treat?

Lazara Karelia Montane Jaime, Patrick E Akpaka, Sehlule Vuma, Angel A Justiz-Vaillant

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Analysis of real-time PCRThe Egyptian journal of medical human genetics · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lazara Karelia Montane JaimeDepartment of Paraclinical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
Patrick E AkpakaDepartment of Paraclinical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
Sehlule VumaDepartment of Paraclinical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
Angel A Justiz-VaillantDepartment of Paraclinical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 56-year-old woman who vaccinated as a child with the Bacillus Calmette-Guerin (BCG), now tests positive to the tuberculin skin test (TST) but test negative to the Quantiferon Gold assay. She has no history of tuberculosis contact and is asymptomatic. This dilemma now is, should be treated for tuberculosis or not, based only on the TST results? To prevent these falsepositive results with TST and avoid treatment with isoniazid (INH) it may be helpful to use interferon-gamma release assay (IGRA) instead, which unlike the TB skin test is not affected by prior BCG vaccination.

Indexed as

Bacillus calmette-guerinGoldIsoniazidMantoux testPurified protein derivativeQuantiferonTuberculin skin testTuberculosis

Identifiers

PMID31720225
PMCPMC6838525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.