Evidence map›Paper›PMID 31720106›Full record

ArticlePeerJ2019

Allelic variant in

Lina Wang, Yongsheng Yuan, Jianwei Wang, Yuting Shen, Yan Zhi, Junyi Li, Min Wang, Kezhong Zhang

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Freezing of gait: overview on etiology, treatment, and future directions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lina Wang *Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yongsheng Yuan *Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jianwei WangDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yuting ShenDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yan ZhiDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Junyi LiDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Min WangDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Kezhong ZhangDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jiangsu Province Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe sought to explore the role of the

methodsOur study recruited 50 PD and 45 healthy control (HC) participants to provide clinical, genetic, and resting state functional magnetic resonance imaging (rs-fMRI) data. All subjects were separated into 16 PD-AA, 34 PD-CA/CC, 14 HC-AA, and 31 HC-CA/CC four subgroups according to

resultsCompared with HC subjects, PD patients exhibited increased ReHo signals in left middle temporal gyrus and decreased ReHo signals in left pallidum. Compared with CA/CC carriers, AA genotype individuals showed abnormal increased ReHo signals in right inferior frontal gyrus (IFG) and supplementary motor area (SMA). Moreover, significant interactions (affected by both disease factor and allelic variation) were detected in right inferior temporal gyrus (ITG). Furthermore, aberrant increased ReHo signals in right ITG were observed in PD-AA in comparison with PD-CA/CC. Notably, ReHo values in right ITG were negatively associated with Tinetti Mobility Test (TMT) gait subscale scores and positively related to Freezing of Gait Questionnaire (FOG-Q) scores in PD-AA subgroup.

conclusionsOur findings suggested that

Indexed as

Gait dysfunctionImaging geneticsParkinson’s diseaseRegional homogeneityrs393795SLC6A3

Identifiers

PMID31720106
PMCPMC6836753
OpenAlexW2985369525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.