Evidence map›Paper›PMID 31720019›Full record

ArticleActa naturae

Surgical Simulation of a Posttraumatic Spinal Cord Glial Scar in Rats.

G B Telegin, A N Minakov, A S Chernov, V N Manskikh, D S Asyutin, N A Konovalov, A G Gabibov

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PubMed Full text at PMC Publisher
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

G B TeleginBranch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Prospect Nauki 6, Pushchino, 142290, Russia.
A N MinakovBranch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Prospect Nauki 6, Pushchino, 142290, Russia.
A S ChernovBranch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Prospect Nauki 6, Pushchino, 142290, Russia.
V N ManskikhM.V. Lomonosov Moscow State University, Leninskie Gory 1, Moscow, 119991, Russia.
D S AsyutinN.N. Burdenko National Scientific and Practical Center for Neurosurgery, RF Health Ministry, 4th Tverskaya-Yamskaya Str. 16, Moscow, 125047, Russia.
N A KonovalovN.N. Burdenko National Scientific and Practical Center for Neurosurgery, RF Health Ministry, 4th Tverskaya-Yamskaya Str. 16, Moscow, 125047, Russia.
A G GabibovShemyakin-Ovchinnikov Institute of bioorganic chemistry, GSP-7, Miklukho-Maklaya Str. 16/10, Moscow, 117997, Russia.
Institute of Bioorganic Chemistry · RUBurdenko Neurosurgery Institute · RUMoscow State University · TJRepublican Scientific and Practical Center of Neurology and Neurosurgery · BY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed and verified an original, minimally invasive method for surgical simulation of a posttraumatic spinal cord glial scar in rats. The model is intended for use as a biological platform for testing the stimulation of regenerative processes in the central nervous system. Unification of the model enables one to achieve versatility both for implantation techniques and for the development of system-action approaches. Faced with a standard structural defect of the spinal cord, researchers will have the unique opportunity to test in vivo promising methods for spinal function recovery in the posttraumatic period. We developed anesthetic support, surgical tactics, and a set of rehabilitation measures for the chronic postoperative period. Experimental exposure effects were preliminarily assessed in vivo using a standard technique for recording the motor activity of rats in the postoperative period of spinal cord injury. Our final conclusions were drawn based on an analysis of histological sections of the rat spinal cord glial scar in three mutually perpendicular planes.

Indexed as

axonal regenerationcryoapplicationglial scarlaboratory ratspinal cord injurysurgical simulationunilateral hemilaminectomy

Identifiers

PMID31720019
PMCPMC6826152
OpenAlexW2982393319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.