Evidence map›Paper›PMID 31719966›Full record

ArticleIranian journal of microbiology2019

Rheumatoid arthritis mediator CD18 expression by

Mahsa Banaei, Gholam Hosein Alishiri, Ramezan Ali Ataee, Ardeshir Hesampoor Mahalati

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mahsa BanaeiApplied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Gholam Hosein AlishiriDepartment of Rheumatology, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Ramezan Ali AtaeeApplied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Ardeshir Hesampoor MahalatiDepartment of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Baqiyatallah University of Medical Sciences · IRIslamic Azad University Central Tehran Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMicrobial superantigens have been reported in the blood and synovial fluid of rheumatoid arthritis patients, raising the question of whether the presence of these superantigens could provoke the induction of inflammatory biomarkers expression or not. The purpose of this study was to examine the MATERIALS AND

methodsThe superantigen C was purified by ultrafiltration. Immunoblotting was performed using a specific antibody. Also, 50 micrograms of superantigens (toxin) were injected intraperitoneally and intra-articularly into separate rat groups. Blood was collected and RNA extracted. Then, the cDNA was synthesized. The expression of CD18 marker was evaluated using RT-real-time PCR, and the results were descriptively analyzed.

resultsThe results of this study revealed that 50 μg of toxin, injected intra-articularly and intraperitoneally, showed the surplus expression of the marker CD18 in the blood of rats after 20 days. By this method, the expression of the marker CD18 was significantly different between rats that received the superantigen intra-articularly and intraperitoneally (2.10; 2.3 and 3.3 folds) and the controls (P≤ 0.05).

conclusionThe results indicated that the presence of

Indexed as

BiomarkerCd18 lymphocytesRheumatoid arthritisStaphylococcal superantigen

Identifiers

PMID31719966
PMCPMC6829107
OpenAlexW2974521104

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.