ArticleCellular and molecular bioengineering2018
Graphene Microelectrode Arrays for Electrical and Optical Measurements of Human Stem Cell-Derived Cardiomyocytes.
Article in Cellular and molecular bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Transparent Graphene Interfaces for Capacitive Recordings from hiPSC-Derived Cardiomyocyte Monolayers: A Proof-of-Concept Study.Sensors (Basel, Switzerland) · 2026Article
- Transparent MXene Microelectrode Arrays for Multimodal Mapping of Neural Dynamics.Advanced healthcare materials · 2025Article
- Graphene Microelectrode Arrays, 4D Structured Illumination Microscopy, and a Machine Learning Spike Sorting Algorithm Permit the Analysis of Ultrastructural Neuronal Changes During Neuronal Signaling in a Model of Niemann-Pick Disease Type C.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Multifunctional Nanomaterials for Advancing Neural Interfaces: Recording, Stimulation, and Beyond.Accounts of chemical research · 2024Review
- Carbon Nanotube-Based Printed All-Organic Microelectrode Arrays for Neural Stimulation and Recording.Micromachines · 2024Article
- The MyoPulser field stimulator, a do it yourself programmable electronic pacemaker for contracting cells and tissues.Scientific reports · 2023Article
- Graphene-based cardiac sensors and actuators.Frontiers in bioengineering and biotechnology · 2023Review
- In Vivo Penetrating Microelectrodes for Brain Electrophysiology.Sensors (Basel, Switzerland) · 2022Review
- Heart-on-Chip for Combined Cellular Dynamics Measurements and Computational Modeling Towards Clinical Applications.Annals of biomedical engineering · 2022Review
- Ultrasensitive two-dimensional material-based MCF-7 cancer cell sensor driven by perturbation processes.Nanoscale advances · 2021Article
- Graphene nanostructures for input-output bioelectronics.Biophysics reviews · 2021Review
- 3D fuzzy graphene microelectrode array for dopamine sensing at sub-cellular spatial resolution.Biosensors & bioelectronics · 2021Article
- Intracellular action potential recordings from cardiomyocytes by ultrafast pulsed laser irradiation of fuzzy graphene microelectrodes.Science advances · 2021Article
- Article
- Mirroring Action Potentials: Label-Free, Accurate, and Noninvasive Electrophysiological Recordings of Human-Derived Cardiomyocytes.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Photo-cross-linkable, insulating silk fibroin for bioelectronics with enhanced cell affinity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids.Science advances · 2019Article
- Cost-effective and multifunctional acquisition system for in vitro electrophysiological investigations with multi-electrode arrays.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introductionCell-cell communication plays a pivotal role in biological systems' coordination and function. Electrical properties have been linked to specification and differentiation of stem cells into targeted progeny, such as neurons and cardiomyocytes. Currently, there is a critical need in developing new ways to complement fluorescent indicators, such as Ca
methodsGraphene, a honeycomb sp
resultsOptical imaging and Raman spectroscopy confirmed the presence of monolayer graphene. Viability assay showed biocompatibility of graphene. Electrochemical characterization proved graphene's functional activity. Nitric acid treatment further enhanced the electrochemical properties of graphene. Graphene electrodes' transparency enabled both optical and electrical recordings from hESC-CMs. Graphene MEA detected changes in beating frequency and field potential duration upon β-adrenergic receptor agonist treatment.
conclusionThe transparent graphene platform enables the investigation of both intracellular and intercellular communication processes and will create new avenues for bidirectional communication (sensing and stimulation) with electrically active tissues and will set the ground for investigations reported diseases such as Alzheimer, Parkinson's disease and arrhythmias.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.