ArticleCellular and molecular bioengineering2018
The Three-Dimensional Microenvironment of the Mitral Valve: Insights into the Effects of Physiological Loads.
Article in Cellular and molecular bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- An Inverse Modeling Approach to Estimate Three-Dimensional Aortic Valve Interstitial Cell Stress Fiber Force Levels.Journal of biomechanical engineering · 2023Article
- Fibroblasts and mouse breast cancer cells can form cellular aggregates in improved soft agar culture medium.Molecular and cellular biochemistry · 2023Article
- The effects of strain history on aortic valve interstitial cell activation in a 3D hydrogel environment.APL bioengineering · 2023Article
- Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral-Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2023Review
- Ex vivo experimental characterizations for understanding the interrelationship between tissue mechanics and collagen microstructure of porcine mitral valve leaflets.Journal of the mechanical behavior of biomedical materials · 2022Article
- Machine Learning for Cardiovascular Biomechanics Modeling: Challenges and Beyond.Annals of biomedical engineering · 2022Review
- On Valve Interstitial Cell Signaling: The Link Between Multiscale Mechanics and Mechanobiology.Cardiovascular engineering and technology · 2021Review
- On the role of predicted in vivo mitral valve interstitial cell deformation on its biosynthetic behavior.Biomechanics and modeling in mechanobiology · 2021Article
- Biology and Biomechanics of the Heart Valve Extracellular Matrix.Journal of cardiovascular development and disease · 2020Review
- Age related extracellular matrix and interstitial cell phenotype in pulmonary valves.Scientific reports · 2020Article
- Growth and remodeling of atrioventricular heart valves: A potential target for pharmacological treatment?Current opinion in biomedical engineering · 2020Article
- Quantifying heart valve interstitial cell contractile state using highly tunable poly(ethylene glycol) hydrogels.Acta biomaterialia · 2019Article
- Analyzing valve interstitial cell mechanics and geometry with spatial statistics.Journal of biomechanics · 2019Article
- An investigation of the glycosaminoglycan contribution to biaxial mechanical behaviours of porcine atrioventricular heart valve leaflets.Journal of the Royal Society, Interface · 2019Article
- Non-Destructive Reflectance Mapping of Collagen Fiber Alignment in Heart Valve Leaflets.Annals of biomedical engineering · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn the mitral valve (MV), numerous pathological factors, especially those resulting from changes in external loading, have been shown to affect MV structure and composition. Such changes are driven by the MV interstitial cell (MVIC) population
methodsWhile cell phenotype, ECM composition and regulation, and tissue level changes in MVIC shape under stress have been studied, a detailed understanding of the three-dimensional (3D) microstructural mechanisms are lacking. As a first step in addressing this challenge, we applied focused ion beam scanning electron microscopy (FIB-SEM) to reveal novel details of the MV microenvironment in 3D.
resultsWe demonstrated that collagen is organized into large fibers consisting of an average of 605 ± 113 fibrils, with a mean diameter of 61.2 ± 9.8 nm. In contrast, elastin was organized into two distinct structural subtypes: (1) sheet-like lamellar elastin, and (2) circumferentially oriented elastin struts, based on both the aspect ratio and transmural tilt. MVICs were observed to have a large cytoplasmic volume, as evidenced by the large mean surface area to volume ratio 3.68 ± 0.35, which increased under physiological loading conditions to 4.98 ± 1.17.
conclusionsOur findings suggest that each MVIC mechanically interacted only with the nearest 3-4 collagen fibers. This key observation suggests that in developing multiscale MV models, each MVIC can be considered a mechanically integral part of the local fiber ensemble and is unlikely to be influenced by more distant structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.