Evidence map›Paper›PMID 31719881›Full record

ArticleCellular and molecular bioengineering2018

Endothelial Cells Exposed to Fluid Shear Stress Support Diffusion Based Maturation of Adult Neural Progenitor Cells.

C M Dumont, J Piselli, S Temple, G Dai, D M Thompson

Abstract read
In one paragraph

Article in Cellular and molecular bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

C M DumontDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180 USA.
J PiselliDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180 USA.
S TempleNeural Stem Cell Institute, Rensselaer, NY 12144 USA.
G DaiDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180 USA.
D M ThompsonDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180 USA.

Funding

Quantifying Changes in Neural Stem Cell Lineages in the Aging NicheR01AG041861 · NIA · REGENERATIVE RESEARCH FOUNDATION · PI COHEN, ANDREW ROBERT, TEMPLE, SALLY · 2012 to 2016
$2.1M
NIA NIH HHS R01 AG041861
6 · The paper itself

Abstract

introductionThe neural stem cell (NSC) niche is a highly complex cellular and biochemical milieu supporting proliferating NSCs and neural progenitor cells (NPCs) with close apposition to the vasculature, primarily comprised of endothelial cells (ECs). Current

methodsIn this work, we developed a novel

resultsNPCs cultured within 10

conclusionsBased on these results, models incorporating ECs exposed to shear stress allow for paracrine signaling gradients and regulate NPC lineage progression with appropriate niche spatial resolution occurring at 10

Indexed as

Endothelial cellsNeural stem cellsNeurogenesisShear stressVascular niche

Identifiers

PMID31719881
PMCPMC6816782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.