ArticleCellular and molecular bioengineering2017
Modelling Human Colonic Smooth Muscle Cell Electrophysiology.
Article in Cellular and molecular bioengineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Modeling based insights into mechanical dysfunction in esophageal motility disorders.PLoS computational biology · 2025Article
- Burst-patterned stimulation restores colonic motility in preclinical models.Science translational medicine · 2025Article
- Computational motility models of neurogastroenterology and neuromodulation.Brain research · 2018Review
- Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.Frontiers in physiology · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The colon is a digestive organ that is subject to a wide range of motility disorders. However, our understanding of the etiology of these disorders is far from complete. In this study, a quantitative single cell model has been developed to describe the electrical behaviour of a human colonic smooth muscle cell (hCSMC). This model includes the pertinent ionic channels and intracellular calcium homoeostasis. These components are believed to contribute significantly to the electrical response of the hCSMC during a slow wave. The major ion channels were constructed based on published data recorded from isolated human colonic myocytes. The whole cell model is able to reproduce experimentally recorded slow waves from human colonic muscles. This represents the first biophysically-detailed model of a hCSMC and provides a means to better understand colonic disorders.
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Registered trials
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